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Stephanoascus ciferrii Complex: The Current State of Infections and Drug Resistance in Humans.
Cosio, Terenzio; Pica, Francesca; Fontana, Carla; Pistoia, Enrico Salvatore; Favaro, Marco; Valsecchi, Isabel; Zarabian, Nikkia; Campione, Elena; Botterel, Françoise; Gaziano, Roberta.
Afiliación
  • Cosio T; Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
  • Pica F; Dermatology Unit, Department of Systems Medicine, Tor Vergata University Hospital, 00133 Rome, Italy.
  • Fontana C; Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
  • Pistoia ES; Laboratory of Microbiology and BioBank, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., 00149 Rome, Italy.
  • Favaro M; Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
  • Valsecchi I; Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
  • Zarabian N; DYNAMYC 7380, Faculté de Santé, Université Paris-Est Créteil (UPEC), 94010 Créteil, France.
  • Campione E; School of Medicine and Health Sciences, George Washington University, 2300 I St NW, Washington, DC 20052, USA.
  • Botterel F; Dermatology Unit, Department of Systems Medicine, Tor Vergata University Hospital, 00133 Rome, Italy.
  • Gaziano R; DYNAMYC 7380, Faculté de Santé, Université Paris-Est Créteil (UPEC), 94010 Créteil, France.
J Fungi (Basel) ; 10(4)2024 Apr 18.
Article en En | MEDLINE | ID: mdl-38667965
ABSTRACT
In recent years, the incidence of fungal infections in humans has increased dramatically, accompanied by an expansion in the number of species implicated as etiological agents, especially environmental fungi never involved before in human infection. Among fungal pathogens, Candida species are the most common opportunistic fungi that can cause local and systemic infections, especially in immunocompromised individuals. Candida albicans (C. albicans) is the most common causative agent of mucosal and healthcare-associated systemic infections. However, during recent decades, there has been a worrying increase in the number of emerging multi-drug-resistant non-albicans Candida (NAC) species, i.e., C. glabrata, C. parapsilosis, C. tropicalis, C. krusei, C. auris, and C. ciferrii. In particular, Candida ciferrii, also known as Stephanoascus ciferrii or Trichomonascus ciferrii, is a heterothallic ascomycete yeast-like fungus that has received attention in recent decades as a cause of local and systemic fungal diseases. Today, the new definition of the S. ciferrii complex, which consists of S. ciferrii, Candida allociferrii, and Candida mucifera, was proposed after sequencing the 18S rRNA gene. Currently, the S. ciferrii complex is mostly associated with non-severe ear and eye infections, although a few cases of severe candidemia have been reported in immunocompromised individuals. Low susceptibility to currently available antifungal drugs is a rising concern, especially in NAC species. In this regard, a high rate of resistance to azoles and more recently also to echinocandins has emerged in the S. ciferrii complex. This review focuses on epidemiological, biological, and clinical aspects of the S. ciferrii complex, including its pathogenicity and drug resistance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Fungi (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Fungi (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza