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Impact of Wildfires on Cardiovascular Health.
Williams, Victoria A; Perreault, Luke R; Yazbeck, Charbel T; Micovic, Nicholas A; Oakes, Jessica M; Bellini, Chiara.
Afiliación
  • Williams VA; Department of Bioengineering, Northeastern University, Boston, MA (V.A.W., C.T.Y., N.A.M., J.M.O., C.B.).
  • Perreault LR; Department of Engineering, Boston College, Chestnut Hill, MA (L.R.P.).
  • Yazbeck CT; Department of Bioengineering, Northeastern University, Boston, MA (V.A.W., C.T.Y., N.A.M., J.M.O., C.B.).
  • Micovic NA; Department of Bioengineering, Northeastern University, Boston, MA (V.A.W., C.T.Y., N.A.M., J.M.O., C.B.).
  • Oakes JM; Department of Bioengineering, Northeastern University, Boston, MA (V.A.W., C.T.Y., N.A.M., J.M.O., C.B.).
  • Bellini C; Department of Bioengineering, Northeastern University, Boston, MA (V.A.W., C.T.Y., N.A.M., J.M.O., C.B.).
Circ Res ; 134(9): 1061-1082, 2024 Apr 26.
Article en En | MEDLINE | ID: mdl-38662865
ABSTRACT
Wildfire smoke (WFS) is a mixture of respirable particulate matter, environmental gases, and other hazardous pollutants that originate from the unplanned burning of arid vegetation during wildfires. The increasing size and frequency of recent wildfires has escalated public and occupational health concerns regarding WFS inhalation, by either individuals living nearby and downstream an active fire or wildland firefighters and other workers that face unavoidable exposure because of their profession. In this review, we first synthesize current evidence from environmental, controlled, and interventional human exposure studies, to highlight positive associations between WFS inhalation and cardiovascular morbidity and mortality. Motivated by these findings, we discuss preventative measures and suggest interventions to mitigate the cardiovascular impact of wildfires. We then review animal and cell exposure studies to call attention on the pathophysiological processes that support the deterioration of cardiovascular tissues and organs in response to WFS inhalation. Acknowledging the challenges of integrating evidence across independent sources, we contextualize laboratory-scale exposure approaches according to the biological processes that they model and offer suggestions for ensuring relevance to the human condition. Noting that wildfires are significant contributors to ambient air pollution, we compare the biological responses triggered by WFS to those of other harmful pollutants. We also review evidence for how WFS inhalation may trigger mechanisms that have been proposed as mediators of adverse cardiovascular effects upon exposure to air pollution. We finally conclude by highlighting research areas that demand further consideration. Overall, we aspire for this work to serve as a catalyst for regulatory initiatives to mitigate the adverse cardiovascular effects of WFS inhalation in the community and alleviate the occupational risk in wildland firefighters.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Humo / Enfermedades Cardiovasculares / Incendios Forestales Límite: Animals / Humans Idioma: En Revista: Circ Res Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Humo / Enfermedades Cardiovasculares / Incendios Forestales Límite: Animals / Humans Idioma: En Revista: Circ Res Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos