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Prepubertal children with obesity have high free IGF-1 levels and accelerated growth despite reduced pappalysin levels.
Martín-Rivada, Álvaro; Martos-Moreno, Gabriel Á; Guerra-Cantera, Santiago; Campillo-Calatayud, Ana; Oxvig, Claus; Frystyk, Jan; Chowen, Julie A; Barrios, Vicente; Argente, Jesús.
Afiliación
  • Martín-Rivada Á; Hospital Infantil Universitario Niño Jesús. Departments of Endocrinology. Research Institute "La Princesa", E-28009, Madrid, Spain.
  • Martos-Moreno GÁ; Department of Pediatrics. Universidad Autónoma de Madrid, E-28029, Madrid, Spain.
  • Guerra-Cantera S; Hospital Infantil Universitario Niño Jesús. Departments of Endocrinology. Research Institute "La Princesa", E-28009, Madrid, Spain.
  • Campillo-Calatayud A; Department of Pediatrics. Universidad Autónoma de Madrid, E-28029, Madrid, Spain.
  • Oxvig C; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutriciόn (CIBEROBN). Instituto de Salud Carlos III, E-28009, Madrid, Spain.
  • Frystyk J; Hospital Infantil Universitario Niño Jesús. Departments of Endocrinology. Research Institute "La Princesa", E-28009, Madrid, Spain.
  • Chowen JA; Department of Pediatrics. Universidad Autónoma de Madrid, E-28029, Madrid, Spain.
  • Barrios V; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutriciόn (CIBEROBN). Instituto de Salud Carlos III, E-28009, Madrid, Spain.
  • Argente J; Hospital Infantil Universitario Niño Jesús. Departments of Endocrinology. Research Institute "La Princesa", E-28009, Madrid, Spain.
J Clin Endocrinol Metab ; 2024 Apr 25.
Article en En | MEDLINE | ID: mdl-38662803
ABSTRACT

BACKGROUND:

Prepubertal children with obesity frequently have enhanced growth, accelerated skeletal maturation and changes in the GH-IGF axis. However, the involvement of pappalysins (PAPP-A, PAPP-A2) and stanniocalcins (STC1, STC2) as regulators of IGF bioavailability has not been studied in obesity.

OBJECTIVE:

We aimed to determine the effects of childhood obesity and weight reduction on serum levels of PAPP-A, PAPP-A2, STC1 and STC2 and their relationship with IGF bioavailability, growth, and other components of the GH-IGF system. PATIENTS AND

METHODS:

Prepubertal children with severe obesity (150, 50% males/females, age 7.72 ± 2.05 years, BMI z-score 4.95 ± 1.70, height z-score 1.28 ± 1.04) were studied at diagnosis and after a minimum of 0.5 BMI z-score reduction. Two hundred and six healthy age- and sex-matched children were used as controls.

RESULTS:

Children with obesity had decreased serum concentrations of PAPP-A, PAPP-A2 and STC2, but increased total and free IGF-I (fIGF-I), intact IGFBP-3, ALS, IGF-II and insulin levels, with no difference in the free/total IGF-I ratio. Neither the standardized BMI nor height correlated with any biochemical parameter analyzed. A decrease in IGF-II, insulin, and ALS with an increase in IGFBP-2 and -5, STC2 and PAPP-A were observed after weight loss.

CONCLUSION:

Increased circulating total and free IGF-I, insulin and IGF-II may all contribute to the increased rate of prepubertal growth and bone maturation observed in children with obesity, with STC2 possibly being involved.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Endocrinol Metab Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Endocrinol Metab Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos