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To characterize small renal cell carcinoma using diffusion relaxation correlation spectroscopic imaging and apparent diffusion coefficient based histogram analysis: a preliminary study.
Dai, Yongming; Zhu, Mengying; Hu, Wentao; Wu, Dongmei; He, Shenyun; Luo, Yuansheng; Wei, Xiaobin; Zhou, Yan; Wu, Guangyu; Hu, Peng.
Afiliación
  • Dai Y; School of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices & Shanghai Clinical Research and Trial Center, ShanghaiTech University, Shanghai, China.
  • Zhu M; Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Hu W; Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Wu D; Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China.
  • He S; Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Luo Y; Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Wei X; Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Zhou Y; Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Wu G; Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. danielrau@163.com.
  • Hu P; School of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices & Shanghai Clinical Research and Trial Center, ShanghaiTech University, Shanghai, China. hupeng@shanghaitech.edu.cn.
Radiol Med ; 129(6): 834-844, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38662246
ABSTRACT

PURPOSE:

To study the capability of diffusion-relaxation correlation spectroscopic imaging (DR-CSI) on subtype classification and grade differentiation for small renal cell carcinoma (RCC). Histogram analysis for apparent diffusion coefficient (ADC) was studied for comparison. MATERIALS AND

METHODS:

A total of 61 patients with small RCC (< 4 cm) were included in the retrospective study. MRI data were reviewed, including a multi-b (0-1500 s/mm2) multi-TE (51-200 ms) diffusion weighted imaging (DWI) sequence. Region of interest (ROI) was delineated manually on DWI to include solid tumor. For each patient, a D-T2 spectrum was fitted and segmented into 5 compartments, and the volume fractions VA, VB, VC, VD, VE were obtained. ADC mapping was calculated, and histogram parameters ADC 90th, 10th, median, standard deviation, skewness and kurtosis were obtained. All MRI metrices were compared between clear cell RCC (ccRCC) and non-ccRCC group, and between high-grade and low-grade group. Receiver operator curve analysis was used to assess the corresponding diagnostic performance.

RESULTS:

Significantly higher ADC 90th, ADC 10th and ADC median, and significantly lower DR-CSI VB was found for ccRCC compared to non-ccRCC. Significantly lower ADC 90th, ADC median and significantly higher VB was found for high-grade RCC compared to low-grade. For identifying ccRCC from non-ccRCC, VB showed the highest area under curve (AUC, 0.861) and specificity (0.882). For differentiating high- from low-grade, ADC 90th showed the highest AUC (0.726) and specificity (0.786), while VB also displayed a moderate AUC (0.715).

CONCLUSION:

DR-CSI may offer improved accuracy in subtype identification for small RCC, while do not show better performance for small RCC grading compared to ADC histogram.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Imagen de Difusión por Resonancia Magnética / Neoplasias Renales Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Radiol Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Imagen de Difusión por Resonancia Magnética / Neoplasias Renales Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Radiol Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Italia