Amniotic Membrane Augmentation for Enucleation After Chemotherapy in Retinoblastoma.
J Pediatr Ophthalmol Strabismus
; 61(4): 291-295, 2024.
Article
en En
| MEDLINE
| ID: mdl-38661308
ABSTRACT
PURPOSE:
To describe amniotic membrane augmentation for enucleation after chemotherapy in retinoblastoma.METHODS:
This was a retrospective study of patients with retinoblastoma who underwent enucleation. The study also evaluated the utility of amniotic membrane grafting in enucleation after chemotherapy in eyes with retinoblastoma.RESULTS:
In this study, 110 eyes of 107 patients were analyzed, and 49 patients had previous systemic chemotherapy, 13 eyes had previous intra-arterial chemotherapy, and 7 eyes had external beam radiation. Amniotic graft was used in 8 eyes (5 following IAC, 2 following systemic chemotherapy, and 1 after both). After IAC, 3 of 7 eyes without amniotic graft had implant exposure compared to 0 of 6 eyes with amniotic graft (P = .05). Pathological examination of the conjunctiva after intra-arterial chemotherapy showed goblet cell hypoplasia that hinders wound healing.CONCLUSIONS:
Amniotic membrane augmentation improves wound integrity in patients with retinoblastoma, especially following intra-arterial chemotherapy. [J Pediatr Ophthalmol Strabismus. 2024;61(4)291-295.].
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Retinoblastoma
/
Enucleación del Ojo
/
Neoplasias de la Retina
/
Amnios
Límite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
J Pediatr Ophthalmol Strabismus
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos