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The Association between Histidine-Rich Glycoprotein rs10770 Genotype and Recurrent Miscarriage in Iranian Women.
Latifimehr, Mahbobeh; Nazari, Leila; Rastegari, Ali Asghar; Zamani, Zahra; Fard-Esfahani, Pezhman.
Afiliación
  • Latifimehr M; Department of Molecular and Cell Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
  • Nazari L; Department of Obstetrics and Gynecology Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Rastegari AA; Department of Molecular and Cell Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
  • Zamani Z; Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran.
  • Fard-Esfahani P; Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran.
Biomed Res Int ; 2024: 2501086, 2024.
Article en En | MEDLINE | ID: mdl-38659607
ABSTRACT

Purpose:

Recurrent miscarriage (RM) is a significant reproductive concern affecting numerous women globally. Genetic factors are believed to play a crucial role in RM, making the histidine-rich glycoprotein (HRG) gene, a topic of interest due to its potential involvement in angiogenesis. This study is aimed at investigating the association between the HRG rs10770 genotype and RM.

Method:

Blood samples were collected from a total of 200 women at the beginning of the study. Subsequently, a comparative analysis was conducted between the blood samples of 100 women with a history of RM (case group) and the blood samples of another 100 healthy women (control group). HRG rs10770 genotyping was performed through polymerase chain reaction restriction-fragment length polymorphism (PCR-RFLP), followed by statistical analysis to evaluate the relationship between HRG rs10770 genotype and RM.

Results:

The results indicated a significant statistical difference between the C/C genotype (OR = 3.32, CI 1.22-9.04, p = 0.01) and the C/T genotype (OR = 1.24, CI 0.67-2.30, p = 0.47) in both the case and control groups. Additionally, a significant correlation was observed in the C allelic frequency among RM participants compared to the control group (OR = 1.65, CI 1.06-2.58, p = 0.02).

Conclusion:

The study highlights the importance of HRG rs10770 in understanding RM, shedding light on its implications for reproductive health. Furthermore, it became evident that women carrying the homozygous C/C genotype exhibited increased susceptibility to the risk of RM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aborto Habitual / Predisposición Genética a la Enfermedad Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Biomed Res Int Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aborto Habitual / Predisposición Genética a la Enfermedad Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Biomed Res Int Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos