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Impact of theta transcranial alternating current stimulation on language production in adult classic galactosemia patients.
Derks, Britt; Kumar, Varsha Shashi; Yadnik, Sai; Panis, Bianca; Bosch, Annet M; Cassiman, David; Janssen, Mirian C H; Schuhmann, Teresa; Rubio-Gozalbo, M Estela; Jansma, Bernadette M.
Afiliación
  • Derks B; Department of Pediatrics, Maastricht University Medical Centre+, MosaKids Children's Hospital, Maastricht, The Netherlands.
  • Kumar VS; Department Clinical Genetics, Maastricht University Medical Centre+, Maastricht, The Netherlands.
  • Yadnik S; GROW, Maastricht University, Maastricht, The Netherlands.
  • Panis B; European Reference Network for Hereditary Metabolic Disorders (MetabERN) Member and United for Metabolic Diseases Member, Udine, Italy.
  • Bosch AM; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.
  • Cassiman D; Maastricht Brain Imaging Centre (MBIC), Maastricht University, Maastricht, The Netherlands.
  • Janssen MCH; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.
  • Schuhmann T; Maastricht Brain Imaging Centre (MBIC), Maastricht University, Maastricht, The Netherlands.
  • Rubio-Gozalbo ME; Department of Pediatrics, Maastricht University Medical Centre+, MosaKids Children's Hospital, Maastricht, The Netherlands.
  • Jansma BM; European Reference Network for Hereditary Metabolic Disorders (MetabERN) Member and United for Metabolic Diseases Member, Udine, Italy.
J Inherit Metab Dis ; 47(4): 703-715, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38659221
ABSTRACT
Patients with classic galactosemia (CG), an inborn error of galactose metabolism, suffer from impairments in cognition, including language processing. Potential causes are atypical brain oscillations. Recent electroencephalogram (EEG) showed differences in the P300 event-related-potential (ERP) and alterations in the alpha/theta-range during speech planning. This study investigated whether transcranial alternating current stimulation (tACS) at theta-frequency compared to sham can cause a normalization of the ERP post stimulation and improves language performance. Eleven CG patients and fourteen healthy controls participated in two tACS-sessions (theta 6.5 Hz/sham). They were engaged in an active language task, describing animated scenes at three moments, that is, pre/during/post stimulation. Pre and post stimulation, behavior (naming accuracy, voice-onset-times; VOT) and mean-amplitudes of ERP were compared, by means of a P300 time-window analysis and cluster-based-permutation testing during speech planning. The results showed that theta stimulation, not sham, significantly reduced naming error-percentage in patients, not in controls. Theta did not systematically speed up naming beyond a general learning effect, which was larger for the patients. The EEG analysis revealed a significant pre-post stimulation effect (P300/late positivity), in patients and during theta stimulation only. In conclusion, theta-tACS improved accuracy in language performance in CG patients compared to controls and altered the P300 and late positive ERP-amplitude, suggesting a lasting effect on neural oscillation and behavior.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electroencefalografía / Estimulación Transcraneal de Corriente Directa / Galactosemias Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Inherit Metab Dis Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electroencefalografía / Estimulación Transcraneal de Corriente Directa / Galactosemias Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Inherit Metab Dis Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos