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Impact of sex on myocardial perfusion following percutaneous coronary intervention of chronic total coronary occlusions.
Somsen, Yvemarie B O; de Winter, Ruben W; Schumacher, Stefan P; van Veelen, Anna; van Diemen, Pepijn A; Jukema, Ruurt A; Hoek, Roel; Stuijfzand, Wynand J; Danad, Ibrahim; Twisk, Jos W R; Verouden, Niels J; Appelman, Yolande; Nap, Alexander; Kleijn, Sebastiaan A; Henriques, José P; Knaapen, Paul.
Afiliación
  • Somsen YBO; Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address: y.somsen@amsterdamumc.nl.
  • de Winter RW; Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address: r.dewinter1@amsterdamumc.nl.
  • Schumacher SP; Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address: s.schumacher@amsterdamumc.nl.
  • van Veelen A; Department of Cardiology Amsterdam UMC, AMC, Amsterdam, the Netherlands. Electronic address: a.vanveelen@amsterdamumc.nl.
  • van Diemen PA; Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address: p.diemen@amsterdamumc.nl.
  • Jukema RA; Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address: r.jukema@amsterdamumc.nl.
  • Hoek R; Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address: roel.hoek@amsterdamumc.nl.
  • Stuijfzand WJ; Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address: w.stuijfzand@amsterdamumc.nl.
  • Danad I; Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address: i.danad@amsterdamumc.nl.
  • Twisk JWR; Department of Epidemiology & Data Science, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address: jwr.twisk@amsterdamumc.nl.
  • Verouden NJ; Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address: c.verouden@amsterdamumc.nl.
  • Appelman Y; Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address: y.appelman@amsterdamumc.nl.
  • Nap A; Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address: a.nap@amsterdamumc.nl.
  • Kleijn SA; Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
  • Henriques JP; Department of Cardiology Amsterdam UMC, AMC, Amsterdam, the Netherlands. Electronic address: j.p.henriques@amsterdamumc.nl.
  • Knaapen P; Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address: p.knaapen@amsterdamumc.nl.
Cardiovasc Revasc Med ; 2024 Apr 13.
Article en En | MEDLINE | ID: mdl-38658269
ABSTRACT

OBJECTIVES:

We sought to investigate the impact of sex on myocardial perfusion changes following chronic total coronary occlusion (CTO) percutaneous coronary intervention (PCI) as measured by [15O]H2O positron-emission tomography (PET) perfusion imaging.

BACKGROUND:

CTO PCI has been associated with an increase in myocardial perfusion, yet females are less likely to undergo revascularization. As such, data on the impact of sex on myocardial perfusion following CTO PCI is scarce.

METHODS:

A total of 212 patients were prospectively enrolled and underwent CTO PCI combined with [15O]H2O PET perfusion imaging prior to and 3 months after PCI. Hyperemic myocardial blood flow (hMBF, mL·min-1·g-1) and coronary flow reserve (CFR) allocated to the CTO territory were quantitatively assessed.

RESULTS:

This study comprised 34 (16 %) females and 178 (84 %) males. HMBF at baseline did not differ between sexes. Females showed a higher increase in hMBF than males (Δ1.34 ± 0.67 vs. Δ1.06 ± 0.74, p = 0.044), whereas post-PCI hMBF was comparable (2.59 ± 0.85 in females vs. 2.28 ± 0.84 in males, p = 0.052). Female sex was independently associated with a higher increase in hMBF after correction for clinical covariates. CFR increase after revascularization was similar in females and males (Δ1.47 ± 0.99 vs. Δ1.30 ± 1.14, p = 0.711).

CONCLUSIONS:

The present study demonstrates a greater recovery of stress perfusion in females compared to males as measured by serial [15O]H2O PET imaging. In addition, a comparable increase in CFR was found in females and males. These results emphasize the benefit of performing CTO PCI in both sexes. CLINICAL PERSPECTIVE What is new? What are the clinical implications?
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cardiovasc Revasc Med Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cardiovasc Revasc Med Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos