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Idiopathic pulmonary fibrosis (IPF): Diagnostic routes using novel biomarkers.
Bartold, Katarzyna; Iskierko, Zofia; Sharma, Piyush Sindhu; Lin, Hung-Yin; Kutner, Wlodzimierz.
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  • Bartold K; Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland.
  • Iskierko Z; Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland.
  • Sharma PS; Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland.
  • Lin HY; Department of Chemical and Materials Engineering, National University of Kaohsiung, Taiwan.
  • Kutner W; Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland; Faculty of Mathematics and Natural Sciences, School of Sciences, Cardinal Stefan Wyszynski University in Warsaw, Warsaw, Poland. Electronic address: wkutner@ichf.edu.pl.
Biomed J ; 47(4): 100729, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38657859
ABSTRACT
Idiopathic pulmonary fibrosis (IPF) diagnosis is still the diagnosis of exclusion. Differentiating from other forms of interstitial lung diseases (ILDs) is essential, given the various therapeutic approaches. The IPF course is now unpredictable for individual patients, although some genetic factors and several biomarkers have already been associated with various IPF prognoses. Since its early stages, IPF may be asymptomatic, leading to a delayed diagnosis. The present review critically examines the recent literature on molecular biomarkers potentially useful in IPF diagnostics. The examined biomarkers are grouped into breath and sputum biomarkers, serologically assessed extracellular matrix neoepitope markers, and oxidative stress biomarkers in lung tissue. Fibroblasts and complete blood count have also gained recent interest in that respect. Although several biomarker candidates have been profiled, there has yet to be a single biomarker that proved specific to the IPF disease. Nevertheless, various IPF biomarkers have been used in preclinical and clinical trials to verify their predictive and monitoring potential.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Fibrosis Pulmonar Idiopática Límite: Humans Idioma: En Revista: Biomed J Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Fibrosis Pulmonar Idiopática Límite: Humans Idioma: En Revista: Biomed J Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos