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The preventive and therapeutic consumption of meat enriched with carob fruit extract, rich in phenolic compounds, improves colonic antioxidant status in late-stage T2DM rats.
Macho-González, Adrián; Apaza Ticona, Luis; Redondo-Castillejo, Rocío; Hernández-Martín, Marina; Sánchez-Muniz, Francisco José; Hernáiz, María José; Bastida, Sara; Benedí, Juana; Bocanegra, Aránzazu; López-Oliva, María Elvira; Mateos-Vega, Carmen; Garcimartín, Alba.
Afiliación
  • Macho-González A; Nutrition and Food Science Department (Nutrition), Pharmacy School, Complutense University of Madrid, Madrid, Spain; AFUSAN Group, Sanitary Research Institute of the San Carlos Clinical Hospital (IdISSC), Spain. Electronic address: amacho@ucm.es.
  • Apaza Ticona L; Organic Chemistry Unit, Department of Chemistry in Pharmaceutical Sciences, Faculty of Pharmacy, Complutense University of Madrid, Spain. Electronic address: lnapaza@ucm.es.
  • Redondo-Castillejo R; Pharmacology, Pharmacognosy and Botany Department, Pharmacy School, Complutense University of Madrid, Madrid, Spain; AFUSAN Group, Sanitary Research Institute of the San Carlos Clinical Hospital (IdISSC), Spain. Electronic address: roredond@ucm.es.
  • Hernández-Martín M; Departmental Section of Physiology, Pharmacy School, Complutense University of Madrid, Madrid, Spain; AFUSAN Group, Sanitary Research Institute of the San Carlos Clinical Hospital (IdISSC), Spain. Electronic address: marinh04@ucm.es.
  • Sánchez-Muniz FJ; Nutrition and Food Science Department (Nutrition), Pharmacy School, Complutense University of Madrid, Madrid, Spain; AFUSAN Group, Sanitary Research Institute of the San Carlos Clinical Hospital (IdISSC), Spain. Electronic address: frasan@ucm.es.
  • Hernáiz MJ; Organic Chemistry Unit, Department of Chemistry in Pharmaceutical Sciences, Faculty of Pharmacy, Complutense University of Madrid, Spain. Electronic address: mjhernai@farm.ucm.es.
  • Bastida S; Nutrition and Food Science Department (Nutrition), Pharmacy School, Complutense University of Madrid, Madrid, Spain; AFUSAN Group, Sanitary Research Institute of the San Carlos Clinical Hospital (IdISSC), Spain. Electronic address: sbastida@ucm.es.
  • Benedí J; Pharmacology, Pharmacognosy and Botany Department, Pharmacy School, Complutense University of Madrid, Madrid, Spain; AFUSAN Group, Sanitary Research Institute of the San Carlos Clinical Hospital (IdISSC), Spain. Electronic address: jbenedi@ucm.es.
  • Bocanegra A; Pharmacology, Pharmacognosy and Botany Department, Pharmacy School, Complutense University of Madrid, Madrid, Spain; AFUSAN Group, Sanitary Research Institute of the San Carlos Clinical Hospital (IdISSC), Spain. Electronic address: aranboca@ucm.es.
  • López-Oliva ME; Departmental Section of Physiology, Pharmacy School, Complutense University of Madrid, Madrid, Spain; AFUSAN Group, Sanitary Research Institute of the San Carlos Clinical Hospital (IdISSC), Spain. Electronic address: elopez@ucm.es.
  • Mateos-Vega C; Biomedicine Sciences Department, Pharmacy School, Alcala University, Madrid, Spain. Electronic address: carmen.mateos@uah.es.
  • Garcimartín A; Pharmacology, Pharmacognosy and Botany Department, Pharmacy School, Complutense University of Madrid, Madrid, Spain; AFUSAN Group, Sanitary Research Institute of the San Carlos Clinical Hospital (IdISSC), Spain. Electronic address: a.garcimartin@ucm.es.
Food Chem ; 450: 139339, 2024 Aug 30.
Article en En | MEDLINE | ID: mdl-38657343
ABSTRACT
Oxidative stress is prevalent in Type 2 Diabetes Mellitus (T2DM) and has been associated with high meat consumption. Carob Fruit Extract (CFE) contains phenolic compounds, making it a suitable functional ingredient. Current study aims to evaluate the effect of CFE-enriched meat (CFE-meat) consumption on the antioxidant status of proximal and distal colon, and its relationship with fecal phenolic compounds in late-stage T2DM rats. Three groups of eight rats were studied 1) D, fed control-meat; 2) ED, fed CFE-meat since the beginning of the study; 3) DE, fed CFE-meat after confirming T2DM. CFE-meat consumption reduces colonic oxidative stress mainly in the proximal section and helps to ameliorate glutathione metabolism and antioxidant score. Difference between ED and DE groups were associated with colon homeostasis and T2DM progression suggesting greater fermentation but lower absorption in the DE group. CFE appears as a promising tool to improve the antioxidant status observed in late-stage T2DM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Extractos Vegetales / Colon / Estrés Oxidativo / Diabetes Mellitus Tipo 2 / Frutas / Antioxidantes Límite: Animals / Humans / Male Idioma: En Revista: Food Chem Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Extractos Vegetales / Colon / Estrés Oxidativo / Diabetes Mellitus Tipo 2 / Frutas / Antioxidantes Límite: Animals / Humans / Male Idioma: En Revista: Food Chem Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido