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Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals.
Grover, Karandeep; Koblova, Alla; Pezacki, Aidan T; Chang, Christopher J; New, Elizabeth J.
Afiliación
  • Grover K; School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.
  • Koblova A; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, New South Wales 2006, Australia.
  • Pezacki AT; School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.
  • Chang CJ; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, New South Wales 2006, Australia.
  • New EJ; Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, United States.
Chem Rev ; 124(9): 5846-5929, 2024 May 08.
Article en En | MEDLINE | ID: mdl-38657175
ABSTRACT
Although transition metals constitute less than 0.1% of the total mass within a human body, they have a substantial impact on fundamental biological processes across all kingdoms of life. Indeed, these nutrients play crucial roles in the physiological functions of enzymes, with the redox properties of many of these metals being essential to their activity. At the same time, imbalances in transition metal pools can be detrimental to health. Modern analytical techniques are helping to illuminate the workings of metal homeostasis at a molecular and atomic level, their spatial localization in real time, and the implications of metal dysregulation in disease pathogenesis. Fluorescence microscopy has proven to be one of the most promising non-invasive methods for studying metal pools in biological samples. The accuracy and sensitivity of bioimaging experiments are predominantly determined by the fluorescent metal-responsive sensor, highlighting the importance of rational probe design for such measurements. This review covers activity- and binding-based fluorescent metal sensors that have been applied to cellular studies. We focus on the essential redox-active metals iron, copper, manganese, cobalt, chromium, and nickel. We aim to encourage further targeted efforts in developing innovative approaches to understanding the biological chemistry of redox-active metals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidación-Reducción / Colorantes Fluorescentes Límite: Animals / Humans Idioma: En Revista: Chem Rev Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidación-Reducción / Colorantes Fluorescentes Límite: Animals / Humans Idioma: En Revista: Chem Rev Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos