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Excited States in Single-Stranded and i-Motif DNA with Silver Ions.
Reveguk, Zakhar V; Khoroshilov, Evgeny V; Sharkov, Andrey V; Pomogaev, Vladimir A; Buglak, Andrey A; Kononov, Alexei I.
Afiliación
  • Reveguk ZV; Department of Molecular Biophysics and Polymer Physics, Saint-Petersburg State University, Universitetskaya nab. 7/9 , 199034 St. Petersburg, Russia.
  • Khoroshilov EV; P.N. Lebedev Physical Institute, Russian Academy of Sciences, 53 Leninsky Pr., 119991 Moscow, Russia.
  • Sharkov AV; P.N. Lebedev Physical Institute, Russian Academy of Sciences, 53 Leninsky Pr., 119991 Moscow, Russia.
  • Pomogaev VA; Department of Molecular Biophysics and Polymer Physics, Saint-Petersburg State University, Universitetskaya nab. 7/9 , 199034 St. Petersburg, Russia.
  • Buglak AA; Department of Physics, Tomsk State University, Tomsk 634050, Russia.
  • Kononov AI; Department of Molecular Biophysics and Polymer Physics, Saint-Petersburg State University, Universitetskaya nab. 7/9 , 199034 St. Petersburg, Russia.
J Phys Chem B ; 128(18): 4377-4384, 2024 May 09.
Article en En | MEDLINE | ID: mdl-38657136
ABSTRACT
We have studied the excited states and structural properties for the complexes of cytosine (dC)10 chains with silver ions (Ag+) in a wide range of the Ag+ to DNA ratio (r) and pH conditions using circular dichroism, steady-state absorption, and fluorescence spectroscopy along with the ultrafast fluorescence upconversion technique. We also calculated vertical electronic transition energies and determined the nature of the corresponding excited states in some models of the cytosine-Ag+ complexes. We show that (dC)10 chains in the presence of silver ions form a duplex stabilized by C-Ag+-C bonds. It is also shown that the i-motif structure formed by (dC)10 chains is destabilized in the presence of Ag+ ions. The excited-state properties in the studied complexes depend on the amount of binding ions and the binding sites, which is supported by the calculations. In particular, new low-lying excited states appear when the second Ag+ ion interacts with the O atom of cytosine in the C-Ag+-C pairs. A similar picture is observed in the case when one Ag+ ion interacts with one cytosine via the N7 atom.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plata / Citosina Idioma: En Revista: J Phys Chem B Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plata / Citosina Idioma: En Revista: J Phys Chem B Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos