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Chagas Cardiomyopathy and Myocardial Sympathetic Denervation.
Gadioli, Leonardo Pippa; Schmidt, André; Maciel, Benedito Carlos; Volpe, Gustavo Jardim; Simões, Marcus Vinicius; Marin-Neto, José Antonio.
Afiliación
  • Gadioli LP; Division of Cardiology, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
  • Schmidt A; Division of Cardiology, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
  • Maciel BC; Division of Cardiology, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
  • Volpe GJ; Division of Cardiology, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
  • Simões MV; Division of Cardiology, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
  • Marin-Neto JA; Division of Cardiology, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. marin_neto@yahoo.com.
Curr Cardiol Rep ; 26(6): 635-641, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38656586
ABSTRACT
PURPOSE OF REVIEW More than a century since its discovery, the pathogenesis of Chagas heart disease (CHD) remains incompletely understood. The role of derangements in the autonomic control of the heart in triggering malignant arrhythmia before the appearance of contractile ventricular impairment was reviewed. RECENT

FINDINGS:

Although previous investigations had demonstrated the anatomical and functional consequences of parasympathetic dysautonomia upon the heart rate control, only recently, coronary microvascular disturbances and sympathetic denervation at the ventricular level have been reported in patients and experimental models of CHD, exploring with nuclear medicine methods their impact on the progression of myocardial dysfunction and cardiac arrhythmias. More important than parasympathetic impaired sinus node regulation, recent evidence indicates that myocardial sympathetic denervation associated with coronary microvascular derangements is causally related to myocardial injury and arrhythmia in CHD. Additionally, 123I-MIBG imaging is a promising tool for risk stratification of progression of ventricular dysfunction and sudden death.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Simpatectomía / Cardiomiopatía Chagásica Límite: Humans Idioma: En Revista: Curr Cardiol Rep Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Simpatectomía / Cardiomiopatía Chagásica Límite: Humans Idioma: En Revista: Curr Cardiol Rep Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos