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Evolution of illness severity in hospital admissions due to COVID-19, Québec, Canada, January to April 2022.
Lo, Ernest; Fortin, Élise; Gilca, Rodica; Trépanier, Pierre-Luc; Geagea, Hany; Zhou, Zhou.
Afiliación
  • Lo E; Institut national de santé publique du Québec, Québec, QC.
  • Fortin É; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, QC.
  • Gilca R; Institut national de santé publique du Québec, Québec, QC.
  • Trépanier PL; Département de microbiologie, Infectiologie et immunologie, Faculté de médecine, Université de Montréal, Québec, QC.
  • Geagea H; Département de médecine sociale et préventive, Faculté de médecine, Université Laval, Québec, QC.
  • Zhou Z; Institut national de santé publique du Québec, Québec, QC.
Can Commun Dis Rep ; 50(1-2): 63-76, 2024 Jan 01.
Article en En | MEDLINE | ID: mdl-38655241
ABSTRACT

Background:

The coronavirus disease 2019 (COVID-19) severity is influenced by multiple factors, such as age, underlying medical conditions, individual immunity, infecting variant, and clinical practice. The highly transmissible Omicron variants resulted in decreased COVID-19 screening capacity, which limited disease severity surveillance.

Objective:

To report on the temporal evolution of disease severity among patients admitted to Québec hospitals due to COVID-19 between January 2, 2022, and April 23, 2022, which corresponded to the peak period of hospitalizations due to Omicron.

Methods:

Retrospective population-based cohort study of all hospital admissions due to COVID-19 in Québec, between January 2, 2022, and April 23, 2022. Study period was divided into four-week periods, corresponding roughly to January, February, March and April. Regression using Cox and Poisson generalized estimating equations (GEEs) was used to quantify temporal variations in length of stay and risk of complications (intensive care admission or in-hospital death) through time, using the Omicron peak (January 2022) as reference. Measures were adjusted for age, sex, vaccination status, presence of chronic diseases, and clustering by hospital.

Results:

During the study period, 9,178 of all 18,272 (50.2%) patients hospitalized with a COVID-19 diagnosis were admitted due to COVID-19. Of these, 1,026 (11.2%) were admitted to intensive care and 1,523 (16.6%) died. Compared to January, the risk of intensive care admission was 25% and 31% lower in March and April respectively, while in-hospital fatality continuously decreased by 45% lower in April. The average length of stay was temporarily lower in March (9%).

Conclusion:

Severity of admissions due to COVID-19 decreased in the first months of 2022, when predominant circulating variants were considered to be of similar severity. Monitoring hospital admissions due to COVID-19 can contribute to disease severity surveillance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Can Commun Dis Rep Asunto de la revista: DOENCAS TRANSMISSIVEIS / EPIDEMIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Canadá
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Can Commun Dis Rep Asunto de la revista: DOENCAS TRANSMISSIVEIS / EPIDEMIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Canadá