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New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals - a PARC (Partnership for the Assessment of Risk from Chemicals) project.
Snapkow, Igor; Smith, Nicola M; Arnesdotter, Emma; Beekmann, Karsten; Blanc, Etienne B; Braeuning, Albert; Corsini, Emanuela; Sollner Dolenc, Marija; Duivenvoorde, Loes P M; Sundstøl Eriksen, Gunnar; Franko, Nina; Galbiati, Valentina; Gostner, Johanna M; Grova, Nathalie; Gutleb, Arno C; Hargitai, Rita; Janssen, Aafke W F; Krapf, Solveig A; Lindeman, Birgitte; Lumniczky, Katalin; Maddalon, Ambra; Mollerup, Steen; Parráková, Lucia; Pierzchalski, Arkadiusz; Pieters, Raymond H H; Silva, Maria J; Solhaug, Anita; Staal, Yvonne C M; Straumfors, Anne; Szatmári, Tünde; Turner, Jonathan D; Vandebriel, Rob J; Zenclussen, Ana Claudia; Barouki, Robert.
Afiliación
  • Snapkow I; Department of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, Norway.
  • Smith NM; Department of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, Norway.
  • Arnesdotter E; Luxembourg Institute of Science and Technology (LIST), Belvaux, Luxembourg.
  • Beekmann K; Wageningen Food Safety Research (WFSR), Part of Wageningen University and Research, Wageningen, Netherlands.
  • Blanc EB; T3S, INSERM UMR-S 1124, Université Paris Cité, Paris, France.
  • Braeuning A; Department of Food Safety, German Federal Institute for Risk Assessment, Berlin, Germany.
  • Corsini E; Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Université degli Studi di Milano, Milan, Italy.
  • Sollner Dolenc M; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
  • Duivenvoorde LPM; Wageningen Food Safety Research (WFSR), Part of Wageningen University and Research, Wageningen, Netherlands.
  • Sundstøl Eriksen G; Norwegian Veterinary Institute, Oslo, Norway.
  • Franko N; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
  • Galbiati V; Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Université degli Studi di Milano, Milan, Italy.
  • Gostner JM; Biochemical Immunotoxicology Group, Institute of Medical Biochemistry, Medical University of Innsbruck, Innsbruck, Austria.
  • Grova N; Immune Endocrine Epigenetics Research Group, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
  • Gutleb AC; Luxembourg Institute of Science and Technology (LIST), Belvaux, Luxembourg.
  • Hargitai R; Unit of Radiation Medicine, Department of Radiobiology and Radiohygiene, National Centre for Public Health and Pharmacy, Budapest, Hungary.
  • Janssen AWF; Wageningen Food Safety Research (WFSR), Part of Wageningen University and Research, Wageningen, Netherlands.
  • Krapf SA; Section for Occupational Toxicology, National Institute of Occupational Health, Oslo, Norway.
  • Lindeman B; Department of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, Norway.
  • Lumniczky K; Unit of Radiation Medicine, Department of Radiobiology and Radiohygiene, National Centre for Public Health and Pharmacy, Budapest, Hungary.
  • Maddalon A; Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Université degli Studi di Milano, Milan, Italy.
  • Mollerup S; Section for Occupational Toxicology, National Institute of Occupational Health, Oslo, Norway.
  • Parráková L; Biochemical Immunotoxicology Group, Institute of Medical Biochemistry, Medical University of Innsbruck, Innsbruck, Austria.
  • Pierzchalski A; Helmholtz Centre for Environmental Research, Leipzig, Germany.
  • Pieters RHH; Innovative Testing in Life Sciences and Chemistry, Research Center for Healthy and Sustainable Living, University of Applied Sciences, Utrecht, Netherlands.
  • Silva MJ; IRAS-Toxicology, Population Health Sciences, Faculty of Veterinary Sciences, Utrecht University, Utrecht, Netherlands.
  • Solhaug A; Department of Human Genetics, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal.
  • Staal YCM; Norwegian Veterinary Institute, Oslo, Norway.
  • Straumfors A; Centre for Health Protection, National Institute of Public Health and the Environment, Bilthoven, Netherlands.
  • Szatmári T; Section for Occupational Toxicology, National Institute of Occupational Health, Oslo, Norway.
  • Turner JD; Unit of Radiation Medicine, Department of Radiobiology and Radiohygiene, National Centre for Public Health and Pharmacy, Budapest, Hungary.
  • Vandebriel RJ; Immune Endocrine Epigenetics Research Group, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
  • Zenclussen AC; Centre for Health Protection, National Institute of Public Health and the Environment, Bilthoven, Netherlands.
  • Barouki R; Helmholtz Centre for Environmental Research, Leipzig, Germany.
Front Toxicol ; 6: 1339104, 2024.
Article en En | MEDLINE | ID: mdl-38654939
ABSTRACT
As a complex system governing and interconnecting numerous functions within the human body, the immune system is unsurprisingly susceptible to the impact of toxic chemicals. Toxicants can influence the immune system through a multitude of mechanisms, resulting in immunosuppression, hypersensitivity, increased risk of autoimmune diseases and cancer development. At present, the regulatory assessment of the immunotoxicity of chemicals relies heavily on rodent models and a limited number of Organisation for Economic Co-operation and Development (OECD) test guidelines, which only capture a fraction of potential toxic properties. Due to this limitation, various authorities, including the World Health Organization and the European Food Safety Authority have highlighted the need for the development of novel approaches without the use of animals for immunotoxicity testing of chemicals. In this paper, we present a concise overview of ongoing efforts dedicated to developing and standardizing methodologies for a comprehensive characterization of the immunotoxic effects of chemicals, which are performed under the EU-funded Partnership for the Assessment of Risk from Chemicals (PARC).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Toxicol Año: 2024 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Toxicol Año: 2024 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Suiza