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Droplet Microfluidics-Assisted Fabrication of Shape Controllable Iron-Alginate Microgels with Fluorescent Property.
Chen, Jie; Shen, Hanyu; Heng, Yicheng; Wang, Songhe; Ardekani, Arezoo; Yang, Yajiang; Hu, Yuandu.
Afiliación
  • Chen J; Department of Materials Science and Engineering, School of Physical Science and Engineering, Beijing Jiaotong University, Beijing, 100044, China.
  • Shen H; Department of Materials Science and Engineering, School of Physical Science and Engineering, Beijing Jiaotong University, Beijing, 100044, China.
  • Heng Y; Department of Materials Science and Engineering, School of Physical Science and Engineering, Beijing Jiaotong University, Beijing, 100044, China.
  • Wang S; Department of Materials Science and Engineering, School of Physical Science and Engineering, Beijing Jiaotong University, Beijing, 100044, China.
  • Ardekani A; Department of Mathematics, School of Mechanical Engineering, Purdue University, West Lafayette, IN, 47906, USA.
  • Yang Y; Key Laboratory of Materials Chemistry for Energy Conversion and Storage (HUST) of Ministry of Education School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan, 430074, China.
  • Hu Y; Department of Materials Science and Engineering, School of Physical Science and Engineering, Beijing Jiaotong University, Beijing, 100044, China.
Macromol Rapid Commun ; 45(14): e2400084, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38653451
ABSTRACT
Droplet-based microfluidics-assisted fabrication of alginate microgels has extensive applications in biomaterials, biomedicines, and related fields. This approach is typically achieved by crosslinking droplets of an aqueous solution of sodium alginate with various divalent and trivalent ions, such as Ca2+, Ba2+, Sr2+, etc. Despite the exceptional features exhibited by bulk alginate hydrogels when using iron ions as the crosslinking reagent, including stimulus responsiveness and complex chemistry, no attention has been given to studying the fabrication of Fe-alginate microgels through droplet microfluidics. In this work, a facile method is presented for fabricating Fe-alginate microgels using single emulsion droplets as templates and an off-chip crosslinking technique to solidify the droplets. The morphologies of the resulting microgels can be systematically adjusted by manipulating different parameters such as viscosities and ionic strength of the collecting solutions. It should be noted that these resulting microgels undergo a color change from light brown to dark brown due to presumed self-oxidation of iron ions within their skeleton structure. Furthermore, these Fe-alginate microgels are functionalized by decorating them with a positively charged linear polymer via electrostatic interactions to impart them with stable fluorescent property. These functionalized Fe-alginate microgels may find potential applications in drug delivery carriers and biomimetic structures.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microfluídica / Alginatos / Microgeles / Hierro Idioma: En Revista: Macromol Rapid Commun Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microfluídica / Alginatos / Microgeles / Hierro Idioma: En Revista: Macromol Rapid Commun Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania