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Ros-responsive nano-platform for lipid-specific fluorescence imaging of atherosclerosis.
Liu, Qi; Li, Shufen; Ma, Di; Chen, Jingruo; Li, Chengming; Zhuang, Weihua; Chen, Mao.
Afiliación
  • Liu Q; Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, Precision Medicine Translational Research Center, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
  • Li S; Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, Precision Medicine Translational Research Center, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
  • Ma D; Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, Precision Medicine Translational Research Center, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
  • Chen J; Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, Precision Medicine Translational Research Center, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
  • Li C; Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, Precision Medicine Translational Research Center, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
  • Zhuang W; Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, Precision Medicine Translational Research Center, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China. Electronic address: weihuaz@scu.edu.cn.
  • Chen M; Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, Precision Medicine Translational Research Center, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China. Electronic address: chenmao@scu.edu.cn.
J Colloid Interface Sci ; 667: 520-528, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38653073
ABSTRACT
Fluorescent probes that specifically targeting Lipid droplets (LDs) have shown potential in biological imaging. Albeit, their in vivo applications are limited due to the hydrophobicity, low signal-to-noise ratio (SNR) and LDs-specificity. Thus, we designed a novel probe namely MeOND, and a reactive oxygen species (ROS)-responsive nano-platform to improve in vivo LDs-specific imaging. MeOND exhibits a remarkable twisted intramolecular charge transfer (TICT) effect with a strongly enhanced near-infrared emission in low-polarity lipid environment. Also, MeOND demonstrates satisfactory biocompatibility and superior intracellular LDs imaging capabilities. MeOND encapsulated nano-platform (MeOND@PMM) presented favorable water solubility and biocompatibility. MeOND@PMM remains stable in physiological conditions but quickly degrades in the environment of elevated ROS level. The released MeOND could then light up the intracellular LDs in atherosclerotic plaques. The design of the probe and nano-platform is expected to provide a better tool for the scientific research of LDs and LDs-related diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Especies Reactivas de Oxígeno / Aterosclerosis / Imagen Óptica / Colorantes Fluorescentes Límite: Animals / Humans Idioma: En Revista: J Colloid Interface Sci Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Especies Reactivas de Oxígeno / Aterosclerosis / Imagen Óptica / Colorantes Fluorescentes Límite: Animals / Humans Idioma: En Revista: J Colloid Interface Sci Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos