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Metastases of primary mixed no-special type and lobular breast cancer display an exclusive lobular histology.
Zels, Gitte; Van Baelen, Karen; De Schepper, Maxim; Borremans, Kristien; Geukens, Tatjana; Isnaldi, Edoardo; Izci, Hava; Leduc, Sophia; Mahdami, Amena; Maetens, Marion; Nguyen, Ha Linh; Pabba, Anirudh; Richard, François; Van Cauwenberge, Josephine; Smeets, Ann; Nevelsteen, Ines; Neven, Patrick; Wildiers, Hans; Van Den Bogaert, Wouter; Floris, Giuseppe; Desmedt, Christine.
Afiliación
  • Zels G; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; Department of Pathology, UZ Leuven, Belgium.
  • Van Baelen K; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; Gynecological Oncology Unit, Department of Gynecology, University Hospitals Leuven, Belgium.
  • De Schepper M; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; Department of Pathology, UZ Leuven, Belgium.
  • Borremans K; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; Gynecological Oncology Unit, Department of Gynecology, University Hospitals Leuven, Belgium.
  • Geukens T; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; General Medical Oncology Unit, Department of Oncology, University Hospitals Leuven, Belgium.
  • Isnaldi E; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium.
  • Izci H; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium.
  • Leduc S; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium.
  • Mahdami A; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium.
  • Maetens M; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium.
  • Nguyen HL; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium.
  • Pabba A; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium.
  • Richard F; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium.
  • Van Cauwenberge J; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; Gynecological Oncology Unit, Department of Gynecology, University Hospitals Leuven, Belgium.
  • Smeets A; Department of Surgical Oncology, University Hospitals Leuven, Leuven, Belgium.
  • Nevelsteen I; Department of Surgical Oncology, University Hospitals Leuven, Leuven, Belgium.
  • Neven P; Gynecological Oncology Unit, Department of Gynecology, University Hospitals Leuven, Belgium.
  • Wildiers H; General Medical Oncology Unit, Department of Oncology, University Hospitals Leuven, Belgium.
  • Van Den Bogaert W; Department of Forensic Medicine, University Hospitals Leuven, Leuven, Belgium.
  • Floris G; Department of Pathology, UZ Leuven, Belgium; Laboratory for Translational Cell & Tissue Research, Department of Imaging & Pathology, KU Leuven, Belgium.
  • Desmedt C; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium. Electronic address: christine.desmedt@kuleuven.be.
Breast ; 75: 103732, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38653060
ABSTRACT
Primary tumors with a mixed invasive breast carcinoma of no-special type (IBC-NST) and invasive lobular cancer (ILC) histology are present in approximately five percent of all patients with breast cancer and are understudied at the metastatic level. Here, we characterized the histology of metastases from two patients with primary mixed IBC-NST/ILC from the postmortem tissue donation program UPTIDER (NCT04531696). The 14 and 43 metastatic lesions collected at autopsy had morphological features and E-cadherin staining patterns consistent with pure ILC. While our findings still require further validation, they may challenge current clinical practice and imaging modalities used in these patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Carcinoma Lobular Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Breast Asunto de la revista: ENDOCRINOLOGIA / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Carcinoma Lobular Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Breast Asunto de la revista: ENDOCRINOLOGIA / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Países Bajos