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Comprehensive review of the repositioning of non-oncologic drugs for cancer immunotherapy.
Rauf, Abdur; Joshi, Payal B; Olatunde, Ahmed; Hafeez, Nabia; Ahmad, Zubair; Hemeg, Hassan A; Aljohani, Abdullah S M; Al Abdulmonem, Waleed; Thiruvengadam, Muthu; Viswanathan, Dhivya; Rajakumar, Govindasamy; Thiruvengadam, Rekha.
Afiliación
  • Rauf A; Department of Chemistry, University of Swabi, Anbar, 23561, Khyber Pakhtunkhwa, Pakistan.
  • Joshi PB; Operations and Method Development, Shefali Research Laboratories, Ambernath, Maharashtra, 421501, India.
  • Olatunde A; Department of Medical Biochemistry, Abubakar Tafawa Balewa University, Bauchi, 740272, Nigeria.
  • Hafeez N; Center of Biotechnology and Microbiology, University of Peshawar, Peshawar, 25120, Khyber Pakhtunkhwa, Pakistan.
  • Ahmad Z; Department of Chemistry, University of Swabi, Anbar, 23561, Khyber Pakhtunkhwa, Pakistan.
  • Hemeg HA; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, P.O. Box 344, Al-Medinah, Al-Monawara, Saudi Arabia.
  • Aljohani ASM; Department of Medical Biosciences, College of Veterinary Medicine, Qassim University, 52571, Buraydah, Saudi Arabia.
  • Al Abdulmonem W; Department of Pathology, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
  • Thiruvengadam M; Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul, 05029, Republic of Korea.
  • Viswanathan D; Center for NanoBioscience, Department of Orthodontics, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Saveetha University, Chennai, Tamil Nadu, 600077, India.
  • Rajakumar G; Center for NanoBioscience, Department of Orthodontics, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Saveetha University, Chennai, Tamil Nadu, 600077, India. microlabsraj@gmail.com.
  • Thiruvengadam R; Center for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, 600077, India. reklak4@gmail.com.
Med Oncol ; 41(5): 122, 2024 Apr 23.
Article en En | MEDLINE | ID: mdl-38652344
ABSTRACT
Drug repositioning or repurposing has gained worldwide attention as a plausible way to search for novel molecules for the treatment of particular diseases or disorders. Drug repurposing essentially refers to uncovering approved or failed compounds for use in various diseases. Cancer is a deadly disease and leading cause of mortality. The search for approved non-oncologic drugs for cancer treatment involved in silico modeling, databases, and literature searches. In this review, we provide a concise account of the existing non-oncologic drug molecules and their therapeutic potential in chemotherapy. The mechanisms and modes of action of the repurposed drugs using computational techniques are also highlighted. Furthermore, we discuss potential targets, critical pathways, and highlight in detail the different challenges pertaining to drug repositioning for cancer immunotherapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reposicionamiento de Medicamentos / Inmunoterapia / Neoplasias Límite: Humans Idioma: En Revista: Med Oncol Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reposicionamiento de Medicamentos / Inmunoterapia / Neoplasias Límite: Humans Idioma: En Revista: Med Oncol Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Estados Unidos