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The Monocle Sign on 18 F-FDG PET Indicates Contralateral Peripheral Facial Nerve Palsy.
Dana, Fatemeh; Maurer, Alexander; Muehlematter, Urs J; Husmann, Lars; Schaab, Jan; Mader, Cäcilia E; Beintner-Skawran, Stephan; Messerli, Michael; Sah, Bert-Ram; Dana, Masih; Dana, Mohsen; Duhnsen, Sjunne H; Mueller, Simon A; Stadler, Thomas; Morand, Grégoire B; Meerwein, Christian; Orita, Erika; Kaufmann, Philipp A; Huellner, Martin W.
Afiliación
  • Dana F; From the Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Maurer A; From the Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Muehlematter UJ; From the Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Husmann L; From the Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Schaab J; From the Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Mader CE; From the Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Beintner-Skawran S; From the Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Messerli M; From the Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Sah BR; From the Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Dana M; Institute of Information Technology Hamfekr Gostar-Mehr-Espadan, Isfahan, Iran.
  • Dana M; Department of Application Development and Distribution, University Hospital Frankfurt, Frankfurt, Germany.
  • Duhnsen SH; Department of Radiology, Spital Limmattal, Zürich, Switzerland.
  • Mueller SA; Department of Oto-Rhino-Laryngology, Head, and Neck Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Stadler T; Department of Oto-Rhino-Laryngology, Head, and Neck Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Meerwein C; Department of Oto-Rhino-Laryngology, Head, and Neck Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Kaufmann PA; From the Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Huellner MW; From the Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Clin Nucl Med ; 49(8): 709-714, 2024 Aug 01.
Article en En | MEDLINE | ID: mdl-38651767
ABSTRACT

BACKGROUND:

The aim of our study was to retrospectively analyze FDG PET/CT data in patients with facial nerve palsy (FNP) for the presence of the monocle sign. PATIENTS AND

METHODS:

A total of 85 patients with unilateral FNP were included into our study, thereof 73 with peripheral FNP and 12 with central FNP. FDG uptake (SUV max , SUV mean , total lesion glycolysis) was measured in both orbicularis oculi muscles (OOMs). FDG uptake of paretic and nonparetic muscles was compared in patients with FNP (Wilcoxon test and Mann-Whitney U test) and was also compared with FDG uptake in 33 patients without FNP (Mann-Whitney U test). SUV max ratios of OOM were compared. A receiver operating characteristic curve and Youden Index were used to determine the optimal cutoff SUV max ratio for the prevalence of contralateral peripheral FNP.

RESULTS:

The SUV max ratio of OOM was significantly higher in patients with peripheral FNP compared with patients with central FNP and those without FNP (1.70 ± 0.94 vs 1.16 ± 0.09 vs 1.18 ± 0.21, respectively; P < 0.001). The SUV max ratio of OOM yielded an area under the curve (AUC) of 0.719 (95% confidence interval, 0.630-0.809), with an optimal cutoff of 1.41, yielding a specificity of 94.4% and a sensitivity of 44.1% for identifying contralateral peripheral FNP. One hundred percent specificity is achieved using a cutoff of 1.91 (sensitivity, 29.4%).

CONCLUSIONS:

Asymmetrically increased FDG uptake of the OOM (the "monocle sign") indicates contralateral peripheral FNP. A nearly 2-fold higher SUV max represents a practically useful cutoff.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fluorodesoxiglucosa F18 / Tomografía Computarizada por Tomografía de Emisión de Positrones Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Nucl Med Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fluorodesoxiglucosa F18 / Tomografía Computarizada por Tomografía de Emisión de Positrones Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Nucl Med Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos