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Intermediate-Term Clinical Outcomes of High-Density Autologous Chondrocyte Implantation in Patients with Concomitant Anterior Cruciate Ligament Reconstruction and Focal Chondral Lesions.
Guillén-Vicente, Isabel; Herros-García, Ramón; Guillén-Vicente, Marta; Ruiz, Borja; Lopez-Alcorocho, Juan Manuel; Rodríguez-Iñigo, Elena; Barrera, Adrián; Fernández-Jaén, Tomás F; Abelow, Steve; Guillén-García, Pedro.
Afiliación
  • Guillén-Vicente I; Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain.
  • Herros-García R; Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain.
  • Guillén-Vicente M; Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain.
  • Ruiz B; Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain.
  • Lopez-Alcorocho JM; Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain.
  • Rodríguez-Iñigo E; Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain.
  • Barrera A; Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain.
  • Fernández-Jaén TF; Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain.
  • Abelow S; Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain.
  • Guillén-García P; Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain.
Cartilage ; : 19476035241247642, 2024 Apr 23.
Article en En | MEDLINE | ID: mdl-38651496
ABSTRACT

OBJECTIVE:

To investigate intermediate-term clinical results in patients with concomitant anterior cruciate ligament (ACL) reconstruction and chondral defect treated with high-density autologous chondrocyte implantation (HD-ACI) compared to patients without ACL tear but with a chondral lesion and HD-ACI treatment.

DESIGN:

Forty-eight patients with focal chondral lesions underwent HD-ACI (24 with ACL reconstruction after an ACL injury and 24 with an intact ACL). Follow-up assessments occurred at 6, 12, and 24 months. Patient-reported knee function and symptoms were assessed using the International Knee Documentation Committee (IKDC) questionnaire, pain was measured using the Visual Analog Scale (VAS), and adverse events were monitored. Physical activity was assessed using the Tegner Activity Level Scale, and cartilage healing was evaluated with the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score.

RESULTS:

No significant adverse events occurred during follow-up. Both groups showed significant improvements at 2 years compared to baseline (VAS 8.0 ± 1.3 to 1.4 ± 2.0 [normal ACL]; 7.4 ± 2.3 to 2.1 ± 2.3 [ACL reconstruction]; IKDC 39.2 ± 10.6 to 76.1 ± 22.0 [intact ACL]; 35.6 ± 12.1 to 74.6 ± 20.9 [ACL reconstruction]). Patients in both groups exceeded the minimal clinically important difference (MCID) for IKDC scores. The Tegner Activity Level Scale decreased immediately after surgery and increased after 2 years, with 70.6% (normal ACL) and 89.5% (ACL reconstruction) returning to their preinjury activity levels. No significant differences in the MOCART score were observed between the groups.

CONCLUSIONS:

ACL reconstruction does not appear to reduce the outcomes (at 2 years) of HD-ACI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cartilage Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cartilage Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos