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Survival trends for left and right sided colon cancer using population-based SEER database: A forty-five-year analysis from 1975 to 2019.
Ulanja, Mark B; Asafo-Agyei, Kwabena Oppong; Neelam, Vijay; Beutler, Bryce D; Antwi-Amoabeng, Daniel; Governor, Samuel B; Rahman, Ganiyu A; Djankpa, Francis T; Ulanja, Reginald N; Nteim, Grace B; Mabrouk, Tarig; Amankwah, Millicent; Alese, Olatunji B.
Afiliación
  • Ulanja MB; CHRISTUS Ochsner St. Patrick Hospital, Lake Charles, Louisiana, USA.
  • Asafo-Agyei KO; CHRISTUS Highland Medical Center, Shreveport, Louisiana, USA.
  • Neelam V; CHRISTUS Ochsner St. Patrick Hospital, Lake Charles, Louisiana, USA.
  • Beutler BD; Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  • Antwi-Amoabeng D; CHRISTUS Ochsner St. Patrick Hospital, Lake Charles, Louisiana, USA.
  • Governor SB; Saint Louis University College for Public Health and Social Justice, Saint Louis, Missouri, USA.
  • Rahman GA; Department of Surgery, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.
  • Djankpa FT; Department of Physiology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.
  • Ulanja RN; Department of Physiology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.
  • Nteim GB; Department of Physiology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.
  • Mabrouk T; CHRISTUS Ochsner St. Patrick Hospital, Lake Charles, Louisiana, USA.
  • Amankwah M; Department of Hematology Oncology, Feist-Weiller Cancer Center, Louisiana State University Health Shreveport, Louisiana, USA.
  • Alese OB; Department of Hematology and Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
Cancer Med ; 13(8): e7145, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38651190
ABSTRACT

BACKGROUND:

Survival differences between left-sided colon cancer (LSCC) and right-sided colon cancer (RSCC) has been previously reported with mixed results, with various study periods not accounting for other causes of mortality.

PURPOSE:

We sought to assess the trends in colon cancer cause- specific survival (CSS) and overall survival (OS) based on sidedness.

METHOD:

Fine-Gray competing risk and Cox models were used to analyze Surveillance, Epidemiology, and End Results (SEER) population-based cohort from 1975 to 2019. Various interval periods were identified based on the timeline of clinical adoption of modern chemotherapy (1975-1989, interval period A; 1990-2004, B; and 2005-2019, C).

RESULTS:

Of the 227,637 patients, 50.1% were female and 46.2% were RSCC. RSCC was more common for African Americans (51.5%), older patients (age ≥65; 51.4%), females (50.4%), while LSCC was more common among Whites (53.1%; p < 0.001), younger patients (age 18-49, 64.6%; 50-64, 62.3%; p < 0.001), males (58.1%; p < 0.001). The Median CSS for LSCC and RCC were 19.3 and 16.7 years respectively for interval period A (1975-1989). Median CSS for interval periods B and C were not reached (more than half of the cohort was still living at the end of the follow-up period). Adjusted CSS was superior for LSCC versus RSCC for the most recent interval period C (HR 0.89; 0.86-0.92; p < 0.001). LSCC consistently showed superior OS for all study periods. Stage stratification showed worse CSS for localized and regional LSCC in the earlier study periods, but the risk attenuated over time. However, left sided distant disease had superior CSS per stage for all interval periods. OS was better for LSCC irrespective of stage, with gradual improvement over time.

CONCLUSION:

LSCC was associated with superior survival compared to right sided tumors. With the adoption of modern chemotherapy regimens, prognosis between LSCC and RSCC became more divergent in favor of LSCC. Colon cancer clinical trials should strongly consider tumor sidedness as an enrollment factor.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Colon / Programa de VERF Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Cancer Med Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Colon / Programa de VERF Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Cancer Med Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos