Your browser doesn't support javascript.
loading
Efficacy and safety of tetrandrine in treatment of rheumatoid arthritis: a meta-analysis. / 汉防己甲素治疗类风湿关节炎有效性和安全性的meta分析.
Xu, Juan; Li, Jichen; Ye, Yan; Zhao, Qingwei; Lyu, Duo.
Afiliación
  • Xu J; Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. xujuan9953@126.com.
  • Li J; Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
  • Ye Y; Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
  • Zhao Q; Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
  • Lyu D; Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine for Clinical Evaluation and Translational Research, Hangzhou 310003, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban ; 53(4): 519-526, 2024 Aug 25.
Article en En, Zh | MEDLINE | ID: mdl-38650449
ABSTRACT

OBJECTIVES:

To explore the efficacy and safety of tetrandrine in the treatment of rheumatoid arthritis.

METHODS:

Randomized controlled studies of tetrandrine in the treatment of rheumatoid arthritis were searched in CNKI, VIP, Wanfang database, SinoMed, PubMed, Springer, Web of Science and Cochrane Central Register of Controlled Trails databases. A meta-analysis was conducted using R 3.5.3 software to evaluate the clinical outcomes, including the total effective rate, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), visual analogue scale (VAS), disease activity score (DAS), tender joint count (TJC), swollen joint count (SJC), and morning stiffness duration, as well as adverse events of rheumatoid arthritis patients.

RESULTS:

A total of 10 articles were included in the study. The meta-analysis indicated that tetrandrine significantly improved the total effective rate (OR=3.27, 95%CI 2.01-5.37, P<0.01), ESR (SMD=1.12, 95%CI 0.06-2.19, P<0.05), CRP (SMD=0.75, 95%CI 0.28-1.22, P<0.01), VAS (SMD=0.64, 95%CI 0.29-1.00, P<0.01), TJC (SMD=1.16, 95%CI 0.58-1.74, P<0.01), SJC (SMD=0.85, 95%CI 0.40-1.31, P<0.01), and morning stiffness (SMD=1.09, 95%CI 0.68-1.50, P<0.01). However, no statistical significance was found in RF (SMD=1.70, 95%CI －1.10-4.51, P>0.05) and DAS (SMD=0.26, 95%CI －0.59-1.11, P>0.05). The overall incidence of adverse events associated with tetrandrine treatment for rheumatoid arthritis was 20% (95%CI 12%-27%, I2=60%, P<0.05), with mild severity and favorable outcomes.

CONCLUSIONS:

Tetrandrine is effective in the treatment of RA patients with a mild degree of adverse events.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Bencilisoquinolinas Límite: Humans Idioma: En / Zh Revista: Zhejiang Da Xue Xue Bao Yi Xue Ban Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Bencilisoquinolinas Límite: Humans Idioma: En / Zh Revista: Zhejiang Da Xue Xue Bao Yi Xue Ban Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China