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Long non-coding RNA SOX2OT in tamoxifen-resistant breast cancer.
Lee, Jeeyeon; Kim, Eun-Ae; Kang, Jieun; Chae, Yee Soo; Park, Ho Yong; Kang, Byeongju; Lee, Soo Jung; Lee, In Hee; Park, Ji-Young; Park, Nora Jee-Young; Jung, Jin Hyang.
Afiliación
  • Lee J; Department of Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
  • Kim EA; Kyungpook National University Chilgok Hospital, Hoguk-ro 807, Buk-gu, 41404, Daegu, Republic of Korea.
  • Kang J; Cell & Matrix Research Institute, Kyungpook National University, Daegu, Republic of Korea.
  • Chae YS; Kyungpook National University Chilgok Hospital, Hoguk-ro 807, Buk-gu, 41404, Daegu, Republic of Korea.
  • Park HY; Department of Oncology/Hematology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
  • Kang B; Kyungpook National University Chilgok Hospital, Hoguk-ro 807, Buk-gu, 41404, Daegu, Republic of Korea.
  • Lee SJ; Department of Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
  • Lee IH; Kyungpook National University Chilgok Hospital, Hoguk-ro 807, Buk-gu, 41404, Daegu, Republic of Korea.
  • Park JY; Department of Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
  • Park NJ; Kyungpook National University Chilgok Hospital, Hoguk-ro 807, Buk-gu, 41404, Daegu, Republic of Korea.
  • Jung JH; Department of Oncology/Hematology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
BMC Mol Cell Biol ; 25(1): 12, 2024 Apr 22.
Article en En | MEDLINE | ID: mdl-38649821
ABSTRACT
Hormone receptor (HR)-positive breast cancer can become aggressive after developing hormone-treatment resistance. This study elucidated the role of long non-coding RNA (lncRNA) SOX2OT in tamoxifen-resistant (TAMR) breast cancer and its potential interplay with the tumor microenvironment (TME). TAMR breast cancer cell lines TAMR-V and TAMR-H were compared with the luminal type A cell line (MCF-7). LncRNA expression was assessed via next-generation sequencing, RNA extraction, lncRNA profiling, and quantitative RT-qPCR. SOX2OT overexpression effects on cell proliferation, migration, and invasion were evaluated using various assays. SOX2OT was consistently downregulated in TAMR cell lines and TAMR breast cancer tissue. Overexpression of SOX2OT in TAMR cells increased cell proliferation and cell invasion. However, SOX2OT overexpression did not significantly alter SOX2 levels, suggesting an independent interaction within TAMR cells. Kaplan-Meier plot analysis revealed an inverse relationship between SOX2OT expression and prognosis in luminal A and B breast cancers. Our findings highlight the potential role of SOX2OT in TAMR breast cancer progression. The downregulation of SOX2OT in TAMR breast cancer indicates its involvement in resistance mechanisms. Further studies should explore the intricate interactions between SOX2OT, SOX2, and TME in breast cancer subtypes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tamoxifeno / Neoplasias de la Mama / Regulación Neoplásica de la Expresión Génica / Movimiento Celular / Resistencia a Antineoplásicos / Proliferación Celular / ARN Largo no Codificante Límite: Female / Humans Idioma: En Revista: BMC Mol Cell Biol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tamoxifeno / Neoplasias de la Mama / Regulación Neoplásica de la Expresión Génica / Movimiento Celular / Resistencia a Antineoplásicos / Proliferación Celular / ARN Largo no Codificante Límite: Female / Humans Idioma: En Revista: BMC Mol Cell Biol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido