Inhibition of UHRF1 Improves Motor Function in Mice with Spinal Cord Injury.
Cell Mol Neurobiol
; 44(1): 39, 2024 Apr 22.
Article
en En
| MEDLINE
| ID: mdl-38649645
ABSTRACT
Spinal-cord injury (SCI) is a severe condition that can lead to limb paralysis and motor dysfunction, and its pathogenesis is not fully understood. The objective of this study was to characterize the differential gene expression and molecular mechanisms in the spinal cord of mice three days after spinal cord injury. By analyzing RNA sequencing data, we identified differentially expressed genes and discovered that the immune system and various metabolic processes play crucial roles in SCI. Additionally, we identified UHRF1 as a key gene that plays a significant role in SCI and found that SCI can be improved by suppressing UHRF1. These findings provide important insights into the molecular mechanisms of SCI and identify potential therapeutic targets that could greatly contribute to the development of new treatment strategies for SCI.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Traumatismos de la Médula Espinal
/
Proteínas Potenciadoras de Unión a CCAAT
/
Ubiquitina-Proteína Ligasas
Límite:
Animals
Idioma:
En
Revista:
Cell Mol Neurobiol
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos