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Tackling the threat of antimicrobial resistance in neonates and children: outcomes from the first WHO-convened Paediatric Drug Optimisation exercise for antibiotics.
Bamford, Alasdair; Masini, Tiziana; Williams, Phoebe; Sharland, Mike; Gigante, Valeria; Dixit, Devika; Sati, Hatim; Huttner, Benedikt; Bin Nisar, Yasir; Cappello, Bernadette; Were, Wilson; Cohn, Jennifer; Penazzato, Martina.
Afiliación
  • Bamford A; Department of Paediatric Infectious Diseases, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; University College London Great Ormond Street Institute of Child Health, London, UK. Electronic address: a.bamford@ucl.ac.uk.
  • Masini T; Research for Health Department, Science Division, WHO, Geneva, Switzerland.
  • Williams P; School of Public Health, Faculty of Medicine, The University of Sydney, Sydney, NSW, Australia; Department of Infectious Diseases, Sydney Children's Hospital Network, Sydney, NSW, Australia.
  • Sharland M; St George's University of London, London, UK.
  • Gigante V; Antimicrobial Resistance Division, WHO, Geneva, Switzerland.
  • Dixit D; Cumming School of Medicine, Department of Pediatrics, Section of Infectious Diseases, University of Calgary, Calgary, AB, Canada.
  • Sati H; Antimicrobial Resistance Division, WHO, Geneva, Switzerland.
  • Huttner B; Antimicrobial Resistance Division, WHO, Geneva, Switzerland.
  • Bin Nisar Y; Department of Maternal, Newborn, Child and Adolescent Health and Ageing, WHO, Geneva, Switzerland.
  • Cappello B; Access to Medicines and Health Products Division, WHO, Geneva, Switzerland.
  • Were W; Department of Maternal, Newborn, Child and Adolescent Health and Ageing, WHO, Geneva, Switzerland.
  • Cohn J; Global Antibiotic Research and Development Partnership, Geneva, Switzerland.
  • Penazzato M; Research for Health Department, Science Division, WHO, Geneva, Switzerland.
Lancet Child Adolesc Health ; 8(6): 456-466, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38648808
ABSTRACT
Children and neonates are highly vulnerable to the impact of antimicrobial resistance. Substantial barriers are faced in relation to research and development of antibacterial agents for use in neonates, children, and adolescents aged yonger than 19 years, and focusing finite resources on the most appropriate agents for development and paediatric optimisation is urgently needed. In November and December, 2022, following the successes of previous similar disease-focused exercises, WHO convened the first Paediatric Drug Optimisation (PADO) exercise for antibiotics, aiming to provide a shortlist of antibiotics to be prioritised for paediatric research and development, especially for use in regions with the highest burden of disease attributable to serious bacterial infection. A range of antibiotics with either existing license for children or in clinical development in adults but with little paediatric data were considered, and PADO priority and PADO watch lists were formulated. This Review provides the background and overview of the exercise processes and its outcomes as well as a concise review of the literature supporting decision making. Follow-up actions to implement the outcomes from the PADO for antibiotics process are also summarised. This Review highlights the major beneficial influence the collaborative PADO process can have, both for therapeutic drug class and disease-specific themes, in uniting efforts to ensure children have access to essential medicines across the world.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Organización Mundial de la Salud / Antibacterianos Límite: Adolescent / Child / Child, preschool / Humans / Infant / Newborn Idioma: En Revista: Lancet Child Adolesc Health Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Organización Mundial de la Salud / Antibacterianos Límite: Adolescent / Child / Child, preschool / Humans / Infant / Newborn Idioma: En Revista: Lancet Child Adolesc Health Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido