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Progress of Mitochondrial Function Regulation in Cardiac Regeneration.
Chen, Yi-Xi; Zhao, An-Ran; Wei, Tian-Wen; Wang, Hao; Wang, Lian-Sheng.
Afiliación
  • Chen YX; Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
  • Zhao AR; Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
  • Wei TW; Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
  • Wang H; Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
  • Wang LS; Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. drlswang@njmu.edu.cn.
J Cardiovasc Transl Res ; 17(5): 1097-1105, 2024 Oct.
Article en En | MEDLINE | ID: mdl-38647881
ABSTRACT
Heart failure and myocardial infarction, global health concerns, stem from limited cardiac regeneration post-injury. Myocardial infarction, typically caused by coronary artery blockage, leads to cardiac muscle cell damage, progressing to heart failure. Addressing the adult heart's minimal self-repair capability is crucial, highlighting cardiac regeneration research's importance. Studies reveal a metabolic shift from anaerobic glycolysis to oxidative phosphorylation in neonates as a key factor in impaired cardiac regeneration, with mitochondria being central. The heart's high energy demands rely on a robust mitochondrial network, essential for cellular energy, cardiac health, and regenerative capacity. Mitochondria's influence extends to redox balance regulation, signaling molecule interactions, and apoptosis. Changes in mitochondrial morphology and quantity also impact cardiac cell regeneration. This article reviews mitochondria's multifaceted role in cardiac regeneration, particularly in myocardial infarction and heart failure models. Understanding mitochondrial function in cardiac regeneration aims to enhance myocardial infarction and heart failure treatment methods and insights.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regeneración / Transducción de Señal / Miocitos Cardíacos / Metabolismo Energético / Insuficiencia Cardíaca / Mitocondrias Cardíacas / Infarto del Miocardio Límite: Animals / Humans Idioma: En Revista: J Cardiovasc Transl Res Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regeneración / Transducción de Señal / Miocitos Cardíacos / Metabolismo Energético / Insuficiencia Cardíaca / Mitocondrias Cardíacas / Infarto del Miocardio Límite: Animals / Humans Idioma: En Revista: J Cardiovasc Transl Res Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos