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Serum testosterone levels and oxidative stress in type 1 diabetes, type 2 diabetes, and obesity.
Ellidag, Hamit Yasar; Aslankoç, Rahime; Kök, Mehmet; Aykal, Güzin; Aydin, Özgür; Özmen, Özlem; Çakir, Remzi Can; Dogan, Ugur.
Afiliación
  • Ellidag HY; Department of Clinical Biochemistry, Antalya Education and Research Hospital of Ministry of Health, Antalya, Türkiye. hayael1980@hotmail.com.
  • Aslankoç R; Department of Physiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Türkiye.
  • Kök M; Department of Internal Medicine, Antalya Education and Research Hospital of Ministry of Health, Antalya, Türkiye.
  • Aykal G; Department of Clinical Biochemistry, Antalya Education and Research Hospital of Ministry of Health, Antalya, Türkiye.
  • Aydin Ö; Department of Clinical Biochemistry, Antalya Education and Research Hospital of Ministry of Health, Antalya, Türkiye.
  • Özmen Ö; Department of Pathology, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University, Burdur, Türkiye.
  • Çakir RC; Department of General Surgery Antalya Education and Research Hospital of Ministry of Health, Antalya, Türkiye.
  • Dogan U; Department of General Surgery Antalya Education and Research Hospital of Ministry of Health, Antalya, Türkiye.
Endokrynol Pol ; 75(2): 183-191, 2024.
Article en En | MEDLINE | ID: mdl-38646988
ABSTRACT

INTRODUCTION:

Obesity, type 1 diabetes mellitus (T1DM), and type 2 diabetes mellitus (T2DM) are metabolic diseases that continue to be a global problem. Testosterone levels in men are affected by several factors, including obesity and DM. Although the relationship between diabetes and testosterone is not fully understood, oxidative stress is thought to play a major role. The aim of this study was to compare serum testosterone levels and oxidative stress markers [total antioxidant status (TAS), total oxidant capacity (TOS), oxidative stress index (OSI), and ischaemic modified albumin (IMA)] among the control group and experimentally induced obese, T1DM, and T2DM rats. MATERIAL AND

METHODS:

The study included 28 male Sprague-Dawley rats divided into 4 groups the obesity group were fed a high-fat diet (HFD), the T2DM group received a HFD plus a single dose of streptozocin (STZ), the T1DM group received only STZ, and there was a control group. Serum testosterone, TAS, TOS, OSI, and IMA were analysed.

RESULTS:

Serum testosterone levels were lower in the T1DM and T2DM groups compared to the control and obesity groups. The TOS levels were highest in the T2DM group, followed by the T1DM group, the obesity group, and finally the control group. No significant difference was found between the obesity group and the control group in terms of TOS levels. Regarding TAS levels, the order observed was control group > obesity group > T2DM > T1DM. Testosterone was positively correlated with TAS and negatively correlated with TOS and OSI.

CONCLUSIONS:

Increased oxidative stress in diabetes may be an important factor that decreases serum testosterone levels.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testosterona / Estrés Oxidativo / Obesidad Límite: Animals Idioma: En Revista: Endokrynol Pol Año: 2024 Tipo del documento: Article Pais de publicación: Polonia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testosterona / Estrés Oxidativo / Obesidad Límite: Animals Idioma: En Revista: Endokrynol Pol Año: 2024 Tipo del documento: Article Pais de publicación: Polonia