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A new benzoquinone and a new stilbenoid from Paphiopedilum exul (Ridl.) Rolfe.
Lertnitikul, Nonthalert; Teerasukpimol, Ladawan; Aekanantakul, Pattatorn; Pooreecharurot, Naphatsawan; Sukrong, Suchada; Boonyong, Cherdsak; Poldorn, Preeyaporn; Rungrotmongkol, Thanyada; Sukandar, Edwin Risky; Aonbangkhen, Chanat; Suttisri, Rutt.
Afiliación
  • Lertnitikul N; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
  • Teerasukpimol L; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
  • Aekanantakul P; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
  • Pooreecharurot N; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
  • Sukrong S; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
  • Boonyong C; Pharmacology and Toxicology Unit, Department of Medical Sciences, Faculty of Science, Rangsit University, Pathumthani, Thailand.
  • Poldorn P; Hong Kong Quantum AI Laboratory, Ltd, University of Hong Kong, Hong Kong, China.
  • Rungrotmongkol T; Center of Excellence in Biocatalyst and Sustainable Biotechnology, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
  • Sukandar ER; Program in Bioinformatics and Computational Biology, Graduate School, Chulalongkorn University, Bangkok, Thailand.
  • Aonbangkhen C; Department of Agro-Industrial, Food, and Environmental Technology, Faculty of Applied Science, King Mongkut's University of Technology North Bangkok (KMUTNB), Bangkok, Thailand.
  • Suttisri R; Center of Excellence in Natural Products Chemistry (CENP), Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
Nat Prod Res ; : 1-9, 2024 Apr 22.
Article en En | MEDLINE | ID: mdl-38646864
ABSTRACT
One new alkyl benzoquinone, paphionone (1), one new trans-stilbenoid, (E)-6,5'-dihydroxy-2,3'-dimethoxystilbene (2), and eight known stilbenoids and flavonoids (3-10) were isolated from the leaves and roots of Paphiopedilum exul (Orchidaceae). Their chemical structures were determined based on IR, ECD, MS and NMR analyses. Cytotoxicity of all isolated compounds towards human hepatocellular carcinoma (HepG2) cell line was examined in vitro by MTT assay. The para-hydroxybenzyl substituted stilbene 10 was potently cytotoxic to the cancer cells, with an IC50 value of 4.80 ± 1.10 µM (selectivity index = 20.83). All compounds were non-toxic to normal human embryo fibroblast (OUMS-36) cell line.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Reino Unido