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Outdoor aeroallergen impacts on asthma exacerbation among sensitized and nonsensitized Philadelphia children.
De Roos, Anneclaire J; Senter, James P; Schinasi, Leah H; Huang, Wanyu; Moore, Kari; Maltenfort, Mitchell; Forrest, Christopher; Henrickson, Sarah E; Kenyon, Chén C.
Afiliación
  • De Roos AJ; Department of Environmental and Occupational Health, Dornsife School of Public Health, Drexel University, Philadelphia, Pa.
  • Senter JP; Urban Health Collaborative, Dornsife School of Public Health, Drexel University, Philadelphia, Pa.
  • Schinasi LH; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pa.
  • Huang W; Department of Environmental and Occupational Health, Dornsife School of Public Health, Drexel University, Philadelphia, Pa.
  • Moore K; Urban Health Collaborative, Dornsife School of Public Health, Drexel University, Philadelphia, Pa.
  • Maltenfort M; Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, Pa.
  • Forrest C; Urban Health Collaborative, Dornsife School of Public Health, Drexel University, Philadelphia, Pa.
  • Henrickson SE; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pa.
  • Kenyon CC; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pa.
J Allergy Clin Immunol Glob ; 3(3): 100248, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38645670
ABSTRACT

Background:

Outdoor aeroallergens, such as pollens and molds, are known triggers of asthma exacerbation; however, few studies have examined children's aeroallergen response based on sensitization.

Objective:

Our aim was to compare the relative impact of aeroallergen levels on asthma exacerbation between pediatric patients with asthma who tested positive or negative for sensitization to particular allergens.

Methods:

A case-crossover design study was conducted to examine associations between outdoor aeroallergen levels and asthma exacerbation events among children living in Philadelphia, Pennsylvania, who were treated within a large pediatric care network. Sensitization to common allergens was characterized in a subset of patients with asthma exacerbation who had undergone skin prick testing (5.5%). Odds ratios (ORs) and 95% CIs were estimated in all patients with asthma exacerbation and in those sensitized or not sensitized to aeroallergens.

Results:

Children who were sensitized to a particular allergen had higher odds of asthma exacerbation with exposure to the allergen (ie, early-season tree pollen, oak tree pollen, early-season weed pollen, and late-season molds) than did all patients with asthma or nonsensitized patients. For example, the association between early-season tree pollen and asthma exacerbation among sensitized children (>90th percentile vs ≤25th, OR = 2.28 [95% CI = 1.23-4.22]) was considerably stronger than that estimated among all patients (OR = 1.34 [95% CI = 1.19-1.50]), and it was also substantially different from the lack of association seen among nonsensitized children (OR = 0.89 [95% CI = 0.51-1.55] [P value for heterogeneity = .03]).

Conclusion:

More prevalent allergy testing may be useful for prevention of asthma exacerbation by informing interventions targeted to sensitized children and tailored for particular aeroallergens.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Allergy Clin Immunol Glob Año: 2024 Tipo del documento: Article País de afiliación: Panamá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Allergy Clin Immunol Glob Año: 2024 Tipo del documento: Article País de afiliación: Panamá Pais de publicación: Estados Unidos