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Ginkgo biloba extract ameliorates skin fibrosis in a bleomycin-induced mouse model of systemic sclerosis.
Lee, Beomgu; Roh, Jong Seong; Jeong, Hoim; Kim, Yerin; Lee, Jihyeon; Yun, Changun; Park, Jiyoung; Kim, Da-Sol; Lee, Jungsoo; So, Min Wook; Kim, Aran; Sohn, Dong Hyun; Lee, Seung-Geun.
Afiliación
  • Lee B; Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Republic of Korea.
  • Roh JS; Department of Herbal Prescription, College of Korean Medicine, Daegu Haany University, Gyeongsan, Republic of Korea.
  • Jeong H; Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Republic of Korea.
  • Kim Y; Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Republic of Korea.
  • Lee J; Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Republic of Korea.
  • Yun C; Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Republic of Korea.
  • Park J; Department of Biological Sciences, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
  • Kim DS; Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
  • Lee J; Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
  • So MW; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
  • Kim A; Division of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
  • Sohn DH; Division of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Republic of Korea.
  • Lee SG; Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Anim Cells Syst (Seoul) ; 28(1): 152-160, 2024.
Article en En | MEDLINE | ID: mdl-38645438
ABSTRACT
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by skin and internal organ fibrosis and obliterative vasculopathy. Few effective treatments are currently available for fibrosis in SSc, therefore, demand persists for novel therapies. Although use of Ginkgo biloba extract (GBE) has been reported to improve blood circulation and alleviate liver and lung fibrosis, its effect on skin fibrosis in SSc remains unclear. In this study, the effects and underlying mechanisms of GBE on skin fibrosis in bleomycin (BLM)-induced mouse model of SSc was investigated. GBE significantly reduced dermal thickness and protein levels of profibrotic factors in the BLM-induced SSc mouse model. Moreover, GBE inhibited the gene expression of profibrotic factors, such as COL1A1, α-SMA, and connective tissue growth factor (CTGF), in fibroblasts by suppressing transforming growth factor (TGF)-ß signaling. Furthermore, GBE inhibited the transdifferentiation of adipocytes into myofibroblasts. Thus, our findings suggest that GBE is a promising therapeutic candidate for the treatment of SSc.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Anim Cells Syst (Seoul) Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Anim Cells Syst (Seoul) Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido