Electrochemical Benzylic C-H Amination via <i>N</i>-Aminopyridinium.

Liu, Jingwei; Du, Jinyao; Zhang, Lin-Bao; Li, Ming; Guo, Weisi

Electrochemical Benzylic C-H Amination via N-Aminopyridinium.

Liu, Jingwei; Du, Jinyao; Zhang, Lin-Bao; Li, Ming; Guo, Weisi.

Afiliación

Liu J; College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology, Qingdao 266042, China.
Du J; College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology, Qingdao 266042, China.
Zhang LB; College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology, Qingdao 266042, China.
Li M; College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology, Qingdao 266042, China.
Guo W; College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology, Qingdao 266042, China.

J Org Chem ; 89(9): 6465-6473, 2024 May 03.

Article en En | MEDLINE | ID: mdl-38644574

ABSTRACT

ABSTRACT

An electrochemical protocol for benzylic C(sp3)-H aminopyridylation via direct C-H/N-H cross-coupling of alkylarenes with N-aminopyridinium triflate has been developed. This method features excellent site-selectivity, broad substrate scope, redox reagent-free and facile scalability. The generated benzylaminopyridiniums can be readily converted to benzylamines via electroreductive N-N bond cleavage.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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