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Brain activation and connection across resting and motor-task states in patients with generalized tonic-clonic seizures.
Jiang, Sisi; Wang, Yuehan; Pei, Haonan; Li, Hechun; Chen, Junxia; Yao, Yutong; Li, Qifu; Yao, Dezhong; Luo, Cheng.
Afiliación
  • Jiang S; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
  • Wang Y; Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, Chengdu, P. R. China.
  • Pei H; High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, P. R. China.
  • Li H; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
  • Chen J; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
  • Yao Y; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
  • Li Q; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
  • Yao D; Department of Neurosurgey, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, P. R. China.
  • Luo C; Department of Neurology, Hainan Medical University, Hainan, P. R. China.
CNS Neurosci Ther ; 30(4): e14672, 2024 04.
Article en En | MEDLINE | ID: mdl-38644561
ABSTRACT

AIMS:

Motor abnormalities have been identified as one common symptom in patients with generalized tonic-clonic seizures (GTCS) inspiring us to explore the disease in a motor execution condition, which might provide novel insight into the pathomechanism.

METHODS:

Resting-state and motor-task fMRI data were collected from 50 patients with GTCS, including 18 patients newly diagnosed without antiepileptic drugs (ND_GTCS) and 32 patients receiving antiepileptic drugs (AEDs_GTCS). Motor activation and its association with head motion and cerebral gradients were assessed. Whole-brain network connectivity across resting and motor states was further calculated and compared between groups.

RESULTS:

All patients showed over-activation in the postcentral gyrus and the ND_GTCS showed decreased activation in putamen. Specifically, activation maps of ND_GTCS showed an abnormal correlation with head motion and cerebral gradient. Moreover, we detected altered functional network connectivity in patients within states and across resting and motor states by using repeated-measures analysis of variance. Patients did not show abnormal connectivity in the resting state, while distributed abnormal connectivity in the motor-task state. Decreased across-state network connectivity was also found in all patients.

CONCLUSION:

Convergent findings suggested the over-response of activation and connection of the brain to motor execution in GTCS, providing new clues to uncover motor susceptibility underlying the disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Descanso / Convulsiones / Encéfalo / Imagen por Resonancia Magnética Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: CNS Neurosci Ther Asunto de la revista: NEUROLOGIA / TERAPEUTICA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Descanso / Convulsiones / Encéfalo / Imagen por Resonancia Magnética Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: CNS Neurosci Ther Asunto de la revista: NEUROLOGIA / TERAPEUTICA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido