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Atrial Cardiomyopathy Predicts the Functional Outcome and Mortality in Stroke Patients.
Liu, Xinjing; Wang, Yuying; Ding, Lan; Hu, Ruiyao; Zhang, Yige; Zhang, Wan; Pei, Lulu; Cao, Yuan; Fang, Hui; Liu, Kai; Sun, Shilei; Wu, Jun; Buonanno, Ferdinando S; Ning, Mingming; Xu, Yuming; Song, Bo.
Afiliación
  • Liu X; Department of Neurology, The First Affiliated Hospital of Zhengzhou University.
  • Wang Y; Department of Neurology, The First Affiliated Hospital of Zhengzhou University.
  • Ding L; Department of Neurology, The First Affiliated Hospital of Zhengzhou University.
  • Hu R; Department of Neurology, The First Affiliated Hospital of Zhengzhou University.
  • Zhang Y; Department of Neurology, The First Affiliated Hospital of Zhengzhou University.
  • Zhang W; Department of Neurology, The First Affiliated Hospital of Zhengzhou University.
  • Pei L; Department of Neurology, The First Affiliated Hospital of Zhengzhou University.
  • Cao Y; Department of Neurology, The First Affiliated Hospital of Zhengzhou University.
  • Fang H; Department of Neurology, The First Affiliated Hospital of Zhengzhou University.
  • Liu K; Department of Neurology, The First Affiliated Hospital of Zhengzhou University.
  • Sun S; Department of Neurology, The First Affiliated Hospital of Zhengzhou University.
  • Wu J; Department of Neurology, The First Affiliated Hospital of Zhengzhou University.
  • Buonanno FS; Department of Cardio-Neurology Division, Massachusetts General Hospital, Harvard Medical School.
  • Ning M; Department of Cardio-Neurology Division, Massachusetts General Hospital, Harvard Medical School.
  • Xu Y; Department of Neurology, The First Affiliated Hospital of Zhengzhou University.
  • Song B; Department of Neurology, The First Affiliated Hospital of Zhengzhou University.
J Atheroscler Thromb ; 31(10): 1416-1426, 2024 Oct 01.
Article en En | MEDLINE | ID: mdl-38644203
ABSTRACT

AIM:

Atrial cardiomyopathy (ACM) is characterized by atrial dysfunction. This study aims to assess the prognostic significance of ACM in patients with noncardioembolic stroke (NCS).

METHODS:

Patients with NCS within seven days of onset were prospectively enrolled between January 2019 and December 2020. ACM was defined as either an N-terminal pro-brain natriuretic peptide (NT-pro BNP) ＞250 pg/ml or a P-terminal force in precordial lead V1 (PTFV1) ≥ 5000µV·ms. A poor functional outcome was determined as a score of 3-6 on the modified Rankin Scale (mRS) within a 2-year follow-up period. Logistic regression and Cox regression analyses were employed to examine the relationship between ACM and the long-term prognosis of patients with NCS.

RESULTS:

A total of 1,346 patients were enrolled, of whom 299 (22.2%) patients were diagnosed with ACM. A total of 207(15.4%) patients experienced a poor functional outcome, and 58 (4.3%) patients died. A multivariate logistic regression analysis indicated that ACM was significantly associated with a poor functional outcome in NCS patients [adjusted odds ratio (aOR) 2.01; 95% confidence interval (CI) 1.42-2.87; p＜0.001]. Additionally, a multivariate Cox regression analysis showed that an NT-pro BNP ＞250 pg/ml was significantly associated with an increased risk of all-cause mortality [adjusted hazard ratio (aHR), 2.51; 95% CI 1.42-4.43; p=0.001].

CONCLUSIONS:

ACM may serve as a novel predictor of a poor long-term functional outcome in patients with NCS. Elevated NT-pro BNP levels (＞250 pg/ml) were found to be associated with a higher risk of all-cause mortality. These findings warrant further validation in multicenter studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptido Natriurético Encefálico / Accidente Cerebrovascular / Cardiomiopatías Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Atheroscler Thromb Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptido Natriurético Encefálico / Accidente Cerebrovascular / Cardiomiopatías Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Atheroscler Thromb Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Japón