Your browser doesn't support javascript.
loading
In Vitro and in Vivo Study of a Photostable Quinone Compound with Enhanced Therapeutic Efficacy against Chagas Disease.
Suto, Yutaka; Inoue, Nagisa; Tagod, Mohammed Suliman Omer; Onizuka, Yoko; Nobuta, Tomoya; Ishii, Mayumi; Inaoka, Daniel Ken; Kanamitsu, Kayoko; Yamagiwa, Noriyuki; Nakajima-Shimada, Junko.
Afiliación
  • Suto Y; Faculty of Pharmacy, Takasaki University of Health and Welfare.
  • Inoue N; Department of Molecular and Cellular Parasitology, Graduate School of Health Sciences, Gunma University.
  • Tagod MSO; Department of Molecular Infection Dynamics, Institute of Tropical Medicine (NEKKEN), Nagasaki University.
  • Onizuka Y; Department of Molecular and Cellular Parasitology, Graduate School of Health Sciences, Gunma University.
  • Nobuta T; Faculty of Pharmacy, Takasaki University of Health and Welfare.
  • Ishii M; Graduate School of Pharmaceutical Sciences, The University of Tokyo.
  • Inaoka DK; Department of Molecular Infection Dynamics, Institute of Tropical Medicine (NEKKEN), Nagasaki University.
  • Kanamitsu K; School of Tropical Medicine and Global Health, Nagasaki University.
  • Yamagiwa N; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo.
  • Nakajima-Shimada J; Graduate School of Pharmaceutical Sciences, The University of Tokyo.
Chem Pharm Bull (Tokyo) ; 72(4): 389-392, 2024.
Article en En | MEDLINE | ID: mdl-38644164
ABSTRACT
Chagas disease, a neglected tropical disease caused by the protozoan Trypanosoma cruzi poses a significant health challenge in rural areas of Latin America. The current pharmacological options exhibit notable side effects, demand prolonged administration, and display limited efficacy. Consequently, there is an urgent need to develop drugs that are safe and clinically effective. Previously, we identified a quinone compound (designated as compound 2) with potent antiprotozoal activity, based on the chemical structure of komaroviquinone, a natural product renowned for its antitrypanosomal effects. However, compound 2 was demonstrated considerably unstable to light. In this study, we elucidated the structure of the light-induced degradation products of compound 2 and probed the correlation between the quinone ring's substituents and its susceptibility to light. Our findings led to the discovery of quinones with significantly enhanced light stability, some of which exhibiting antitrypanosomal activity. The most promising compound was evaluated for drug efficacy in a mouse model of Chagas disease, revealing where a notable reduction in blood parasitemia.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinonas / Tripanocidas / Trypanosoma cruzi / Enfermedad de Chagas Límite: Animals Idioma: En Revista: Chem Pharm Bull (Tokyo) Año: 2024 Tipo del documento: Article Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinonas / Tripanocidas / Trypanosoma cruzi / Enfermedad de Chagas Límite: Animals Idioma: En Revista: Chem Pharm Bull (Tokyo) Año: 2024 Tipo del documento: Article Pais de publicación: Japón