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Maslinic acid supplementation prevents di(2-ethylhexyl) phthalate-induced apoptosis via PRDX6 in peritubular myoid cells of Chinese forest musk deer.
Cao, Heran; Li, Zhenpeng; Jin, Tianqi; He, Shuyang; Liu, Shujuan; Li, Long; Wang, Yang; Gong, Ye; Wang, Gang; Yang, Fangxia; Dong, Wuzi.
Afiliación
  • Cao H; College of Animal Science and Technology, Northwest A&F University, Shaanxi 712100, China.
  • Li Z; College of Animal Science and Technology, Northwest A&F University, Shaanxi 712100, China; Shaanxi Qiyuan-Times Agri-Tech Development Co. Ltd., Shaanxi 725000, China.
  • Jin T; College of Animal Science and Technology, Northwest A&F University, Shaanxi 712100, China; Biology Research Centre of Qin-Mountains Wildlife, Northwest A&F University, Shaanxi 712100, China.
  • He S; College of Forestry, Northwest A&F University, Shaanxi 712100, China; Biology Research Centre of Qin-Mountains Wildlife, Northwest A&F University, Shaanxi 712100, China.
  • Liu S; College of Animal Science and Technology, Northwest A&F University, Shaanxi 712100, China.
  • Li L; College of Animal Science and Technology, Northwest A&F University, Shaanxi 712100, China; Biology Research Centre of Qin-Mountains Wildlife, Northwest A&F University, Shaanxi 712100, China.
  • Wang Y; College of Animal Science and Technology, Northwest A&F University, Shaanxi 712100, China; Biology Research Centre of Qin-Mountains Wildlife, Northwest A&F University, Shaanxi 712100, China; Shaanxi Qiyuan-Times Agri-Tech Development Co. Ltd., Shaanxi 725000, China.
  • Gong Y; College of Animal Science and Technology, Northwest A&F University, Shaanxi 712100, China; Shaanxi Qiyuan-Times Agri-Tech Development Co. Ltd., Shaanxi 725000, China.
  • Wang G; Shaanxi Qiyuan-Times Agri-Tech Development Co. Ltd., Shaanxi 725000, China.
  • Yang F; College of Forestry, Northwest A&F University, Shaanxi 712100, China; Biology Research Centre of Qin-Mountains Wildlife, Northwest A&F University, Shaanxi 712100, China. Electronic address: yangfangxia@nwsuaf.edu.cn.
  • Dong W; College of Animal Science and Technology, Northwest A&F University, Shaanxi 712100, China; Biology Research Centre of Qin-Mountains Wildlife, Northwest A&F University, Shaanxi 712100, China.
J Environ Sci (China) ; 143: 47-59, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38644023
ABSTRACT
Chinese forest musk deer (FMD), an endangered species, have exhibited low reproductive rates even in captivity due to stress conditions. Investigation revealed the presence of di(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, in the serum and skin of captive FMDs. Feeding FMDs with maslinic acid (MA) has been observed to alleviate the stress response and improve reproductive rates, although the precise molecular mechanisms remain unclear. Therefore, this study aims to investigate the molecular mechanisms underlying the alleviation of DEHP-induced oxidative stress and cell apoptosis in primary peritubular myoid cells (PMCs) through MA intake. Primary PMCs were isolated and exposed to DEHP in vitro. The results demonstrated that DEHP significantly suppressed antioxidant levels and promoted cell apoptosis in primary PMCs. Moreover, interfering with the expression of PRDX6 was found to induce excessive reactive oxygen species (ROS) production and cell apoptosis in primary PMCs. Supplementation with MA significantly upregulated the expression of PRDX6, thereby attenuating DEHP-induced oxidative stress and cell apoptosis in primary PMCs. These findings provide a theoretical foundation for mitigating stress levels and enhancing reproductive capacity of in captive FMDs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ciervos / Apoptosis / Estrés Oxidativo / Dietilhexil Ftalato Límite: Animals Idioma: En Revista: J Environ Sci (China) Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ciervos / Apoptosis / Estrés Oxidativo / Dietilhexil Ftalato Límite: Animals Idioma: En Revista: J Environ Sci (China) Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos