Your browser doesn't support javascript.
loading
Targeted metabolomics profiling in pregnancy associated with vitamin D deficiency.
Li, Xiaogang; An, Zhuoling; Yao, Aimin; Li, Rui; Zhang, Suhan; Yu, Songlin; Ma, Liangkun; Liu, Yanping.
Afiliación
  • Li X; Department of Clinical Nutrition, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 1 Shuaifuyuan Road, Beijing, 100730, China.
  • An Z; Biobank Facility, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
  • Yao A; Pharmacy Department of Beijing Chao Yang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.
  • Li R; Department of Gynaecology and Obstetrics, Shunyi Women's and Children's Hospital, Beijing, People's Republic of China.
  • Zhang S; Department of Clinical Nutrition, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 1 Shuaifuyuan Road, Beijing, 100730, China.
  • Yu S; Department of Obstetrics and Gynecology, State Key Laboratory of Complex Severe and Rare Diseases, Academic Medical Science and Peking, Peking Union Medical College Hospital, Union Medical College, Beijing, 100730, People's Republic of China.
  • Ma L; Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Academic Medical Science and Peking, Peking Union Medical College Hospital, Union Medical College, Beijing, 100730, People's Republic of China.
  • Liu Y; Department of Obstetrics and Gynecology, State Key Laboratory of Complex Severe and Rare Diseases, Academic Medical Science and Peking, Peking Union Medical College Hospital, Union Medical College, Beijing, 100730, People's Republic of China. maliangkun@pumch.cn.
BMC Pregnancy Childbirth ; 24(1): 295, 2024 Apr 20.
Article en En | MEDLINE | ID: mdl-38643102
ABSTRACT

BACKGROUND:

Vitamin D deficiency is common in pregnancy, however, its effects has not been fully elucidated. Here, we conducted targeted metabolomics profiling to study the relationship.

METHODS:

This study enrolled 111 pregnant women, including sufficient group (n = 9), inadequate group (n = 49) and deficient group (n = 53). Ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)-based targeted metabonomics were used to characterize metabolite profiles associated with vitamin D deficiency in pregnancy.

RESULTS:

Many metabolites decreased in the inadequate and deficient group, including lipids, amino acids and others. The lipid species included fatty acyls (FA 143, FA 260; O), glycerolipids (MG 182), glycerophospholipids (LPG 205, PE-Cer 401; O2, PG 290), sterol lipids (CE 205, ST 280; O4, ST 281; O4). Decreased amino acids included aromatic amino acids (tryptophan, phenylalanine, tyrosine) and branched-chain amino acids (valine, isoleucine, leucine), proline, methionine, arginine, lysine, alanine, L-kynurenine,5-hydroxy-L-tryptophan, allysine.

CONCLUSIONS:

This targeted metabolomics profiling indicated that vitamin D supplementation can significantly affect lipids and amino acids metabolism in pregnancy.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina D / Espectrometría de Masas en Tándem Límite: Female / Humans / Pregnancy Idioma: En Revista: BMC Pregnancy Childbirth Asunto de la revista: OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina D / Espectrometría de Masas en Tándem Límite: Female / Humans / Pregnancy Idioma: En Revista: BMC Pregnancy Childbirth Asunto de la revista: OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido