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Caspase-3/Gasdermin E-mediated pyroptosis contributes to Ricin toxin-induced inflammation.
Xu, Yuxin; Dong, Mingxin; Sun, Chengbiao; Wang, Yan; Zhao, Na; Yu, Kaikai; Lu, Nan; Xu, Na; Liu, Wensen; Wu, Congmei.
Afiliación
  • Xu Y; School of Chemistry and Life Science, Changchun University of Technology, Changchun 130012, China.
  • Dong M; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Science, Changchun 130122, China.
  • Sun C; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Science, Changchun 130122, China.
  • Wang Y; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Science, Changchun 130122, China; Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
  • Zhao N; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Science, Changchun 130122, China.
  • Yu K; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Science, Changchun 130122, China.
  • Lu N; School of Life Science and Technology, Changchun University of Science and Technology, Changchun 130022, China.
  • Xu N; Jilin Medical University, Jilin 132013, China. Electronic address: xunajlu@sina.com.
  • Liu W; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Science, Changchun 130122, China. Electronic address: liuws85952@163.com.
  • Wu C; School of Chemistry and Life Science, Changchun University of Technology, Changchun 130012, China. Electronic address: wucmyue@163.com.
Toxicol Lett ; 396: 19-27, 2024 May 15.
Article en En | MEDLINE | ID: mdl-38642674
ABSTRACT
Ricin toxin (RT) is highly cytotoxic and can release a considerable amount of pro-inflammatory factors due to depurination, causing excessive inflammation that may aggravate the harm to the body. Pyroptosis, a type of gasdermin-mediated cell death, is a contributor to the exacerbation of inflammation. Accumulating evidence indicate that pyroptosis plays a significant role in the pathogen infection and tissue injury, suggesting a potential correlation between pyroptosis and RT-induced inflammation. Here, we aim to demonstrate this correlation and explore its molecular mechanisms. Results showed that RT triggers mouse alveolar macrophage MH-S cells pyroptosis by activating caspase-3 and cleaving Gasgermin E (GSDME). In contrast, inhibition of caspase-3 with Z-DEVD-FMK (inhibitor of caspase-3) or knockdown of GSDME attenuates this process, suggesting the essential role of caspase-3/GSDME-mediated pyroptosis in contributing to RT-induced inflammation. Collectively, our study enhances our understanding of a novel mechanism of ricin cytotoxicity, which may emerge as a potential target in immunotherapy to control the RT-induced inflammation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ricina / Caspasa 3 / Piroptosis / Inflamación Límite: Animals Idioma: En Revista: Toxicol Lett Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ricina / Caspasa 3 / Piroptosis / Inflamación Límite: Animals Idioma: En Revista: Toxicol Lett Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos