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Effect of Day 3 cell number on the live birth rate of vitrified-warmed Day 5 single blastocyst transfer in young women.
Qiu, Pingping; Ye, Ronghui; Li, Ping; Huang, Hui; Ding, Lu.
Afiliación
  • Qiu P; Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361000, Fujian, China.
  • Ye R; Xiamen Key Laboratory of Reproduction and Genetics, Xiamen, 361000, Fujian, China.
  • Li P; Xiamen Assisted Reproductive Technology Quality Control Center, Xiamen, 361000, Fujian, China.
  • Huang H; Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361000, Fujian, China.
  • Ding L; Xiamen Key Laboratory of Reproduction and Genetics, Xiamen, 361000, Fujian, China.
BMC Pregnancy Childbirth ; 24(1): 289, 2024 Apr 19.
Article en En | MEDLINE | ID: mdl-38641596
ABSTRACT

BACKGROUND:

Previous studies have reported inconsistent results regarding blastocyst selection with a high day 3 (D3) cell number and the eventual pregnancy outcomes. Thus, in this study, the relationship between the D3 cell number and clinical outcomes of day 5 single blastocyst transfer (SBT) in vitrified-warmed transfer cycles was investigated.

METHODS:

Our retrospective study included 1144 day 5 SBT in vitrified-warmed cycles between February 2016 and February 2021. All cycles were the first vitrified-warmed cycles, and the female patients were less than 35 years of age. Based on the D3 cell number, the cycles were divided into four groups, as follows group A (3-7 cells, n = 130); group B (8-9 cells, n = 621); group C (10-12 cells, n = 328); and group D (13-16 cells, n = 65). The differences in the live birth rate (LBR), clinical pregnancy rate, and miscarriage rate were examined among the four groups.

RESULTS:

The LBR and clinical pregnancy rate increased with the D3 cell number (P < 0.01). No significant difference was found in the miscarriage rate among the groups (P = 0.055). After adjusting for confounding factors, the LBR was significantly higher in groups C (odds ratio [OR] = 1.477, 95% confidence interval [CI] 1.124-1.941, P = 0.005) and D (OR = 2.000, 95% CI 1.166-3.429, P = 0.012) than in group B.

CONCLUSIONS:

A high D3 cell number (> 9 cells) was associated with a high LBR in the vitrified-warmed day 5 SBT cycles of patients < 35 years of age. The cell number of D3 embryos can be an important reference indicator for blastocyst selection. Among blastocysts with the same morphological score, those with > 9 cells on D3 can be preferentially selected for transplantation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aborto Espontáneo / Tasa de Natalidad Límite: Female / Humans / Pregnancy Idioma: En Revista: BMC Pregnancy Childbirth Asunto de la revista: OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aborto Espontáneo / Tasa de Natalidad Límite: Female / Humans / Pregnancy Idioma: En Revista: BMC Pregnancy Childbirth Asunto de la revista: OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido