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Auditory P50 Sensory Gating Alterations in Major Depressive Disorder and their Relationship to Clinical Symptoms.
de la Salle, Sara; Bowers, Hayley; Birmingham, Meagan; Phillips, Jennifer L; Blier, Pierre; Knott, Verner.
Afiliación
  • de la Salle S; University of Ottawa Institute of Mental Health Research at The Royal, Ottawa, ON, Canada; School of Psychology, University of Ottawa, ON, Canada.
  • Bowers H; University of Ottawa Institute of Mental Health Research at The Royal, Ottawa, ON, Canada.
  • Birmingham M; University of Ottawa Institute of Mental Health Research at The Royal, Ottawa, ON, Canada.
  • Phillips JL; University of Ottawa Institute of Mental Health Research at The Royal, Ottawa, ON, Canada; Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada.
  • Blier P; University of Ottawa Institute of Mental Health Research at The Royal, Ottawa, ON, Canada; Department of Cellular & Molecular Medicine, University of Ottawa, ON, Canada; Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada.
  • Knott V; University of Ottawa Institute of Mental Health Research at The Royal, Ottawa, ON, Canada; School of Psychology, University of Ottawa, ON, Canada; Department of Cellular & Molecular Medicine, University of Ottawa, ON, Canada; Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada. El
Psychiatry Res Neuroimaging ; 341: 111813, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38640589
ABSTRACT
Cognitive deficits in depression are pervasive and include impairments in attention and higher-order functions but the degree to which low-level sensory processes are affected is unclear. The present work examined event-related potential (P50 and N100) features of auditory sensory gating (i.e., the ability to inhibit P50/N100 responses to redundant stimuli) and their relationship to depressive symptoms, including ruminations and dysfunctional attitudes. In 18 patients with major depressive disorder (MDD) and 18 healthy volunteers, auditory sensory gating was measured using a paired-stimulus paradigm yielding ratio (rP50, rN100) and difference (dP50, dN100) gating indices, which reflected amplitude reductions from first (S1) to second (S2) stimulus. Patients with MDD exhibited diminished rP50 and dP50 gating scores and delayed S1-N100 latencies compared to healthy volunteers. These measures were positively associated with ruminative thoughts, negative attitudes and degree of depression. Study findings implicate aberrant sensory processing in depressed patients that is related to severity of maladaptive thinking.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Depresivo Mayor / Electroencefalografía / Potenciales Evocados Auditivos / Filtrado Sensorial Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Depresivo Mayor / Electroencefalografía / Potenciales Evocados Auditivos / Filtrado Sensorial Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Países Bajos