Ethanolic Extract of Xylopia aethiopica Attenuated Aluminum-Induced Ovarian Toxicity in Adult Female Wistar Rats.
JBRA Assist Reprod
; 28(2): 284-288, 2024 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-38640350
ABSTRACT
OBJECTIVE:
Aluminum is a widely used metal in homes and industries. Xylopia aethiopica is an important medicinal plant with antioxidant properties. The objective of this study is to investigate the ameliorative potential of Xylopia aethiopica on aluminum-induced ovarian toxicity in Wistar rat.METHODS:
Twenty-five rats were randomized into five groups with five rats per group. Group 1 received only distilled water; Group 2 received 150mg/kg of aluminum chloride; Group 3 received 150mg/kg aluminum chloride with 100/kg Xylopia aethiopica seed extracts; Group 4 received 150mg/kg aluminum chloride with 50 mg/kg Xylopia aethiopica seed extracts, and Group 5 received 150mg/kg aluminum chloride with 50mg/Kg zinc sulphate. For twenty-one days, all administrations were done orally. The rats were then sacrificed following chloroform anesthesia. The ovaries were harvested for histological examination.RESULTS:
The data were analyzed on IBM SPSS software version 21 and the differences in mean values were considered significant at p<0.05. Xylopia aethiopica extracts significantly (p<0.05) reversed the detrimental effects of aluminum chloride on luteinizing hormone, follicle stimulating hormone, progesterone and estradiol. The histological analysis of the ovaries showed a significant improvement in rats treated with Xylopia aethiopica extract and zinc sulphate. However, Xylopia aethiopica was more effective in a dose-dependent manner.CONCLUSIONS:
This study suggests that Xylopia aethiopica has ameliorative potential on aluminum-induced toxicity in the ovaries of adult female Wistar Rats.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ovario
/
Extractos Vegetales
/
Ratas Wistar
/
Xylopia
Límite:
Animals
Idioma:
En
Revista:
JBRA Assist Reprod
Año:
2024
Tipo del documento:
Article
País de afiliación:
Nigeria
Pais de publicación:
Brasil