Rhodium(III)-Catalyzed Switchable ß-C(sp<sup>2</sup>)-H Alkenylation and Alkylation of Acyclic Enamides with Allyl Alcohols.

Li, Xiaolan; Liu, Jie; Song, Ruixin; Luo, Xuzhong; Luo, Haiqing

Rhodium(III)-Catalyzed Switchable ß-C(sp²)-H Alkenylation and Alkylation of Acyclic Enamides with Allyl Alcohols.

Li, Xiaolan; Liu, Jie; Song, Ruixin; Luo, Xuzhong; Luo, Haiqing.

Afiliación

Li X; College of Chemistry, Nanchang University, Nanchang, Jiangxi 330031, China.
Liu J; Department of Chemistry & Chemical Engineering, Gannan Normal University, Ganzhou 341000, China.
Song R; Department of Chemistry & Chemical Engineering, Gannan Normal University, Ganzhou 341000, China.
Luo X; Department of Chemistry & Chemical Engineering, Gannan Normal University, Ganzhou 341000, China.
Luo H; College of Chemistry, Nanchang University, Nanchang, Jiangxi 330031, China.

Org Lett ; 26(17): 3673-3678, 2024 May 03.

Article en En | MEDLINE | ID: mdl-38639408

ABSTRACT

ABSTRACT

Herein, rhodium(III)-catalyzed ß-C(sp2)-H alkenylation and alkylation of enamides are presented using readily accessible allylic alcohols by switching the reaction conditions. This tunable transformation has been applied to a wide range of substrates and typically proceeded with excellent regioselectivity and stereoselectivity as well as with good functional group tolerance. The catalytic system offers an efficient approach for synthesizing various functionalized enamides bearing N-(2Z,4E)-butadiene and (Z)-ß-C(sp2)-H alkylated enamides. In addition, mechanistic experiments suggest that Rh(III)-catalyzed C-H activation is not related to the critical step.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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