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Propofol Alleviates Anxiety-Like Behaviors Associated with Pain by Inhibiting the Hyperactivity of PVNCRH Neurons via GABAA Receptor ß3 Subunits.
Yu, Le; Zhu, Xiaona; Peng, Kang; Qin, Huimin; Yang, Kexin; Cai, Fang; Hu, Ji; Zhang, Ye.
Afiliación
  • Yu L; Department of Anesthesiology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
  • Zhu X; Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230032, China.
  • Peng K; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
  • Qin H; Department of Anesthesiology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
  • Yang K; Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230032, China.
  • Cai F; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
  • Hu J; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
  • Zhang Y; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Adv Sci (Weinh) ; 11(28): e2309059, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38639389
ABSTRACT
Pain, a comorbidity of anxiety disorders, causes substantial clinical, social, and economic burdens. Emerging evidence suggests that propofol, the most commonly used general anesthetic, may regulate psychological disorders; however, its role in pain-associated anxiety is not yet described. This study investigates the therapeutic potential of a single dose of propofol (100 mg kg-1) in alleviating pain-associated anxiety and examines the underlying neural mechanisms. In acute and chronic pain models, propofol decreased anxiety-like behaviors in the elevated plus maze (EPM) and open field (OF) tests. Propofol also reduced the serum levels of stress-related hormones including corticosterone, corticotropin-releasing hormone (CRH), and norepinephrine. Fiber photometry recordings indicated that the calcium signaling activity of CRH neurons in the paraventricular nucleus (PVNCRH) is reduced after propofol treatment. Interestingly, artificially activating PVNCRH neurons through chemogenetics interfered with the anxiety-reducing effects of propofol. Electrophysiological recordings indicated that propofol decreases the activity of PVNCRH neurons by increasing spontaneous inhibitory postsynaptic currents (sIPSCs). Further, reducing the levels of γ-aminobutyric acid type A receptor ß3 (GABAAß3) subunits in PVNCRH neurons diminished the anxiety-relieving effects of propofol. In conclusion, this study provides a mechanistic and preclinical rationale to treat pain-associated anxiety-like behaviors using a single dose of propofol.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Núcleo Hipotalámico Paraventricular / Conducta Animal / Propofol / Receptores de GABA-A / Modelos Animales de Enfermedad / Neuronas Límite: Animals Idioma: En Revista: Adv Sci (Weinh) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Núcleo Hipotalámico Paraventricular / Conducta Animal / Propofol / Receptores de GABA-A / Modelos Animales de Enfermedad / Neuronas Límite: Animals Idioma: En Revista: Adv Sci (Weinh) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania