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Genomic Catastrophe (Chromothripsis and Polyploidy) Correlates With Tumor Distribution in Extrauterine High-grade Serous Carcinoma.
Yoon, Ju-Yoon; Sharma, Aarti; Ligon, Azra H; Ramesh, Rebecca G; Soong, T Rinda; Xian, Wa; Chapel, David B; Crum, Christopher P.
Afiliación
  • Yoon JY; Department of Pathology, Unity Health Toronto, Toronto, Canada.
  • Sharma A; Department of Pathology, Division of Women's and Perinatal Pathology.
  • Ligon AH; Department of Pathology, Division of Clinical Cytogenetics, Brigham and Women's Hospital, Boston, MA.
  • Ramesh RG; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia.
  • Soong TR; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA.
  • Xian W; Department of Biology and Biochemistry, Stem Cell Center, University of Houston, Houston, TX.
  • Chapel DB; Department of Pathology, University of Michigan Health, Ann Arbor, MI.
  • Crum CP; Department of Pathology, Division of Women's and Perinatal Pathology.
Am J Surg Pathol ; 48(8): 1017-1023, 2024 Aug 01.
Article en En | MEDLINE | ID: mdl-38639044
ABSTRACT
Most extrauterine high-grade serous carcinomas (HGSCs) are thought to develop first in the distal fallopian tube. Most models of HGSC assume origin from relatively stable, noninvasive serous tubal intraepithelial carcinomas. However, widespread tumor involvement in the absence of a serous tubal intraepithelial carcinoma could occur after catastrophic genomic events (CGEs; such as chromothripsis or polyploidy). Twenty-six HGSCs assigned to fallopian tube (n = 9, group 1) and/or ovary (n = 9, group 2), and primary peritoneal (n = 8, group 3) were assessed by microarray (Oncoscan). CGEs were identified in 15/26 (57.7%); chromothripsis-like pattern in 13/26 (50.0%) and polyploidy in 6/26 (23.1%). CGE was seen in 4/9 (44.4%), 9/9 (100%), and 2/8 (25%) cases in groups 1. 2, and 3, respectively. Overall, CGEs were seen in 9/9 (100%) cases with grossly evident ovarian parenchymal involvement versus 6/17 (35.3%) without ( P = 0.0024). Ovarian size (measured on the long axis) correlated with CGE positivity ( P = 0.016). CGEs are significantly more common in HGSCs with ovarian parenchymal involvement compared with those limited to the fallopian tube and/or extraovarian tissues. These associations suggest geographically different tumor growth patterns and support the subdivision of HGSCs according to not only the stage but also tumor distribution. They have implications for clinical and pathologic presentation, trajectory of tumor evolution, and in the case of primary peritoneal HGSCs, potentially unique precursors to tumor transitions that could inform or influence cancer prevention efforts.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias Peritoneales / Poliploidía / Cistadenocarcinoma Seroso / Neoplasias de las Trompas Uterinas / Clasificación del Tumor / Cromotripsis Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Am J Surg Pathol Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias Peritoneales / Poliploidía / Cistadenocarcinoma Seroso / Neoplasias de las Trompas Uterinas / Clasificación del Tumor / Cromotripsis Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Am J Surg Pathol Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos