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Longitudinal Evaluation of the Distribution of Intraretinal Hyper-Reflective Foci in Eyes with Intermediate Age-Related Macular Degeneration.
Verma, Aditya; Nittala, Muneeswar G; Corradetti, Giulia; Nassisi, Marco; Velaga, Swetha B; He, Ye; Haines, Jonathan L; Pericak-Vance, Margaret A; Stambolian, Dwight; Sadda, SriniVas R.
Afiliación
  • Verma A; Doheny Eye Institute, Pasadena, CA, USA.
  • Nittala MG; Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY, USA.
  • Corradetti G; Doheny Eye Institute, Pasadena, CA, USA.
  • Nassisi M; Doheny Eye Institute, Pasadena, CA, USA.
  • Velaga SB; Department of Ophthalmology, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
  • He Y; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
  • Haines JL; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Pericak-Vance MA; Doheny Eye Institute, Pasadena, CA, USA.
  • Stambolian D; Doheny Eye Institute, Pasadena, CA, USA.
  • Sadda SR; Department of Ophthalmology, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
Curr Eye Res ; : 1-7, 2024 Apr 19.
Article en En | MEDLINE | ID: mdl-38639042
ABSTRACT

PURPOSE:

Intraretinal hyper-reflective foci (IHRF) are optical coherence tomography (OCT) risk factors for progression of age-related macular degeneration (AMD). In this study we assess the change in the number and distribution of IHRF over two years.

METHODS:

The axial distribution of IHRF were quantified in eyes with intermediate AMD (iAMD) at baseline and 24 months, using a series of 5 sequential equidistant en face OCT retinal slabs generated between the outer border of the internal limiting membrane (ILM) and the inner border of the retinal pigment epithelium (RPE). Following thresholding and binarization, IHRF were quantified in each retinal slab using ImageJ. The change in IHRF number in each slab between baseline and month 24 was calculated.

RESULTS:

Fifty-two eyes showed evidence of IHRF at baseline, and all continued to show evidence of IHRF at 24 months (M24). The total average IHRF count/eye increased significantly from 4.67 ± 0.63 at baseline to 11.62 ± 13.86 at M24 (p < 0.001) with a mean increase of 6.94 ± 11.12 (range - 9 to + 60). Overall, at M24, 76.9% eyes showed an increase in IHRF whereas 15.4% of eyes showed a decrease (3 eyes [5.7%] showed no change). There was a greater number of IHRF and a greater increase in IHRF over M24 in the outer slabs.

CONCLUSIONS:

IHRF are most common in the outer retinal layers and tend to increase in number over time. The impact of the distribution and frequency of these IHRF on the overall progression of AMD requires further study.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Eye Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Eye Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido