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The Efficacy of the Combination of Continuous Femoral Nerve Block and Intravenous Parecoxib on Rehabilitation in Patients Undergoing Total Knee Arthroplasty: A Double-Blind, Randomized Clinical Trial.
Sarridou, Despoina; Gkiouliava, Anna; Argiriadou, Helena; Varrassi, Giustino; Chalmouki, Georgia; Vadalouca, Athina; Moka, Eleni.
Afiliación
  • Sarridou D; Anesthesiology and Intensive Care, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, GRC.
  • Gkiouliava A; Anesthesiology and Intensive Care, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, GRC.
  • Argiriadou H; Anesthesiology and Intensive Care, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, GRC.
  • Varrassi G; Pain Medicine, Paolo Procacci Foundation, Rome, ITA.
  • Chalmouki G; Anesthesiology, Asklepieion Voulas General Hospital, Athens, GRC.
  • Vadalouca A; Pain and Palliative Care, Athens Medical Center, Athens, GRC.
  • Moka E; Anesthesiology, Creta InterClinic Hospital, Herakleion, GRC.
Cureus ; 16(3): e56420, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38638774
ABSTRACT
BACKGROUND AND

AIM:

The optimal strategy for the management of postoperative pain after total knee arthroplasty (TKA) remains challenging, while its treatment is crucial to increase patients' outcomes. This study aimed to investigate the effects of parecoxib as add-on therapy, in a standard postoperative pain management protocol, represented by the continuous femoral nervous block. We studied its influence on rehabilitation indices and pain scores in patients undergoing TKA. MATERIAL AND

METHODS:

This is a single-center, prospective, double-blind, randomized, placebo-controlled trial. All patients were operated with the use of subarachnoid anesthesia, and divided into two groups for postoperative analgesia. Both groups received a continuous femoral nerve block. One of the groups received intravenous parecoxib, while the other received a placebo. The primary investigated outcome was the range of motion (ROM). Recordings were noted at different times postoperatively. Bromage score (BS), visual analog scale (VAS), and the State-Trait Anxiety Inventory (STAI) were also studied.

RESULTS:

A total of 90 patients were included and analyzed. ROM was significantly better (p<0.001) and pain scores were significantly lower (p=0.007) in the parecoxib group. No statistically significant difference was found with regard to BS between the two groups. A significant correlation was found between ROM and VAS pain scores at 12 hours (p=0.02), while ROM was inversely correlated with STAI postoperatively.

CONCLUSIONS:

The use of intravenous parecoxib is effective in improving rehabilitation indices and provides decreased postoperative pain scores after TKA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos