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Clinical Evaluation of Next-generation, Multi-weight Hyaluronic Acid Plus Antioxidant Complex-based Topical Formulations with Targeted Delivery to Enhance Skin Rejuvenation.
Lain, Edward; Mariwalla, Kavita; Zeichner, Joshua; Kirchner, Frank; Ruvolo, Eduardo; Draelos, Zoe D.
Afiliación
  • Lain E; Dr. Lain is with Sanova Dermatology in Austin, Texas.
  • Mariwalla K; Dr. Mariwalla is with Mariwalla Dermatology in West Islip, New York.
  • Zeichner J; Dr. Zeichner is with the Department of Dermatology at Mount Sinai Hospital in New York, New York.
  • Kirchner F; Dr. Kirchner and Mr. Ruvolo are with Beiersdorf Inc. in Florham Park, New Jersey.
  • Ruvolo E; Dr. Kirchner and Mr. Ruvolo are with Beiersdorf Inc. in Florham Park, New Jersey.
  • Draelos ZD; Dr. Draelos is with Dermatology Consulting Services in High Point, North Carolina.
J Clin Aesthet Dermatol ; 17(4): 12-16, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38638188
ABSTRACT

Introduction:

Hyaluronic acid (HA) has become a commonly used ingredient in many topical products due to its strong humectant properties and essential role in skin hydration; however, limitations of delivery of HA to only the surface of skin has hindered leveraging the full capacity of HA biology necessary for skin rejuvenation. Here, we describe the clinical efficacy data of a set of novel next-generation, multi-weight HA plus antioxidant complex-based topical formulations with targeted skin delivery to enhance skin rejuvenation.

Methods:

Four multi-weight HA plus antioxidant complex-based formulations 1) Multi-Weight HA plus Antioxidant Complex Lotion with SPF 30 (Day Lotion); 2) Multi-Weight HA plus Antioxidant Complex Cream (Night Cream); 3) Multi-Weight HA plus Antioxidant Complex Gel Cream; and 4) Multi-Weight HA plus Antioxidant Complex Boost Serum were clinically evaluated for key attributes including moisturization via corneometer, with clinical grading of dryness, roughness, fine lines and wrinkles, and following daily use of the individual products for up to eight weeks.

Results:

Daily use of the multi-weight HA plus antioxidant complex-based formulations demonstrated significant improvements in all parameters evaluated compared to baselines, with changes in moisturization observed within 30 minutes of application, and changes in clinical grading parameters of dryness, roughness, fine lines and wrinkles observed as early as two weeks.

Conclusion:

These data demonstrate the clinical benefits of daily use of multi-weight HA plus antioxidant complex-based moisturizers for overall improvement in skin health and appearance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Aesthet Dermatol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Aesthet Dermatol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos