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The indirect costs of human papillomavirus-related cancer in Central and Eastern Europe: years of life lost and productivity costs.
Sabale, Ugne; Karamousouli, Eugenia; Popovic, Lazar; Krasznai, Zoárd Tibor; Harrop, Daniel; Meiwald, Anne; Hughes, Robert; Weston, Georgie; Bencina, Goran.
Afiliación
  • Sabale U; Center for Observational and Real-World Evidence (CORE), MSD, Vilnius, Lithuania.
  • Karamousouli E; MSD, Athens, Greece.
  • Popovic L; Faculty of Medicine, Oncology Institute of Vojvodina, University of Novi Sad, Novi Sad, Serbia.
  • Krasznai ZT; Faculty of Medicine, Department of Obstetrics and Gynecology, University of Debrecen, Debrecen, Hungary.
  • Harrop D; Adelphi Values PROVE, Bollington, UK.
  • Meiwald A; Adelphi Values PROVE, Bollington, UK.
  • Hughes R; Adelphi Values PROVE, Bollington, UK.
  • Weston G; Adelphi Values PROVE, Bollington, UK.
  • Bencina G; Center for Observational and Real-World Evidence, MSD, Madrid, Spain.
J Med Econ ; 27(sup2): 1-8, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38638098
ABSTRACT

BACKGROUND:

Human papilloma virus (HPV) is a common cause of several types of cancer, including head and neck (oral cavity, pharynx, oropharynx, hypopharynx, nasopharynx, and larynx), cervical, vulval, vaginal, anal, and penile cancers. As HPV vaccines are available, there is potential to prevent HPV-related disease burden and related costs.

METHOD:

A model was developed for nine Central Eastern European (CEE) countries (Bulgaria, Croatia, Czechia, Hungary, Poland, Romania, Serbia, Slovakia, Slovenia). This model considered cancer patients who died from 11 HPV-related cancers (oropharynx, oral cavity, nasopharynx, hypopharynx, pharynx, anal, larynx, vulval, vaginal, cervical, and penile) in 2019. Due to data limitations, Bulgaria only included four cancer types. The model estimated the number of HPV-related deaths and years of life lost (YLL) based on published HPV-attributable fractions. YLL was adjusted with labor force participation, retirement age and then multiplied by mean annual earnings, discounted at a 3% annual rate to calculate the present value of future lost productivity (PVFLP).

RESULTS:

In 2019, there were 6,832 deaths attributable to HPV cancers resulting in 107,846 YLL in the nine CEE countries. PVFLP related to HPV cancers was estimated to be €46 M in Romania, €37 M in Poland, €19 M in Hungary, €15 M in Czechia, €12 M in Croatia, €10 M in Serbia, €9 M in Slovakia, €7 M in Bulgaria and €4 M in Slovenia.

CONCLUSIONS:

There is a high disease burden of HPV-related cancer-related deaths in the CEE region, with a large economic impact to society due to substantial productivity losses. It is critical to implement and reinforce public health measures with the aim to reduce the incidence of HPV-related diseases, and the subsequent premature cancer deaths. Improving HPV screening and increasing vaccination programs, in both male and female populations, could help reduce this burden.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Costo de Enfermedad / Infecciones por Papillomavirus Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Med Econ Asunto de la revista: SERVICOS DE SAUDE Año: 2024 Tipo del documento: Article País de afiliación: Lituania Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Costo de Enfermedad / Infecciones por Papillomavirus Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Med Econ Asunto de la revista: SERVICOS DE SAUDE Año: 2024 Tipo del documento: Article País de afiliación: Lituania Pais de publicación: Reino Unido