Your browser doesn't support javascript.
loading
Comparing the bone regeneration potential between a trabecular bone and a porous scaffold through osteoblast migration and differentiation: A multiscale approach.
Majumder, Santanu; Gupta, Abhisek; Das, Ankita; Barui, Ananya; Das, Mitun; Chowdhury, Amit Roy.
Afiliación
  • Majumder S; Department of Aerospace Engineering and Applied Mechanics, Indian Institute of Engineering Science and Technology, Howrah, India.
  • Gupta A; Department of Aerospace Engineering and Applied Mechanics, Indian Institute of Engineering Science and Technology, Howrah, India.
  • Das A; Centre for Healthcare Science and Technology, Indian Institute of Engineering Science and Technology, Howrah, India.
  • Barui A; Centre for Healthcare Science and Technology, Indian Institute of Engineering Science and Technology, Howrah, India.
  • Das M; Bioceramics and Coating Division, CSIR-Central Glass & Ceramic Research Institute, Kolkata, India.
  • Chowdhury AR; Department of Aerospace Engineering and Applied Mechanics, Indian Institute of Engineering Science and Technology, Howrah, India.
Int J Numer Method Biomed Eng ; 40(6): e3821, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38637289
ABSTRACT
Both cell migration and osteogenic differentiation are critical for successful bone regeneration. Therefore, understanding the mechanobiological aspects that govern these two processes is essential in designing effective scaffolds that promote faster bone regeneration. Studying these two factors at different locations is necessary to manage bone regeneration in various sections of a scaffold. Hence, a multiscale computational model was used to observe the mechanical responses of osteoblasts placed in different positions of the trabecular bone and gyroid scaffold. Fluid shear stresses in scaffolds at cell seeded locations (representing osteogenic differentiation) and strain energy densities in cells at cell substrate interface (representing cell migration) were observed as mechanical response parameters in this study. Comparison of these responses, as two critical factors for bone regeneration, between the trabecular bone and gyroid scaffold at different locations, is the overall goal of the study. This study reveals that the gyroid scaffold exhibits higher osteogenic differentiation and cell migration potential compared to the trabecular bone. However, the responses in the gyroid only mimic the trabecular bone in two out of nine positions. These findings can guide us in predicting the ideal cell seeded sites within a scaffold for better bone regeneration and in replicating a replaced bone condition by altering the physical parameters of a scaffold.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoblastos / Osteogénesis / Regeneración Ósea / Diferenciación Celular / Movimiento Celular / Andamios del Tejido / Hueso Esponjoso Límite: Humans Idioma: En Revista: Int J Numer Method Biomed Eng Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoblastos / Osteogénesis / Regeneración Ósea / Diferenciación Celular / Movimiento Celular / Andamios del Tejido / Hueso Esponjoso Límite: Humans Idioma: En Revista: Int J Numer Method Biomed Eng Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido