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Determinants of physical quality of life in patients with chronic thromboembolic pulmonary hypertension after treatment: Insights from invasive exercise stress test.
Watabe, Kosuke; Goda, Ayumi; Tobita, Kazuki; Yokoyama, Sachi; Kikuchi, Hanako; Takeuchi, Kaori; Inami, Takumi; Soejima, Kyoko; Kohno, Takashi.
Afiliación
  • Watabe K; Department of Cardiovascular Medicine, Kyorin University Hospital, Tokyo, Japan.
  • Goda A; Department of Cardiovascular Medicine, Kyorin University Hospital, Tokyo, Japan. Electronic address: ayumix34@yahoo.co.jp.
  • Tobita K; Department of Rehabilitation, Kyorin University Hospital, Tokyo, Japan.
  • Yokoyama S; Department of Rehabilitation, Kyorin University Hospital, Tokyo, Japan; Nursing Department, Yumino Heart Clinic, Tokyo, Japan.
  • Kikuchi H; Department of Cardiovascular Medicine, Kyorin University Hospital, Tokyo, Japan.
  • Takeuchi K; Department of Cardiovascular Medicine, Kyorin University Hospital, Tokyo, Japan.
  • Inami T; Department of Cardiovascular Medicine, Kyorin University Hospital, Tokyo, Japan.
  • Soejima K; Department of Cardiovascular Medicine, Kyorin University Hospital, Tokyo, Japan.
  • Kohno T; Department of Cardiovascular Medicine, Kyorin University Hospital, Tokyo, Japan.
J Heart Lung Transplant ; 43(8): 1278-1287, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38636934
ABSTRACT

BACKGROUND:

Impaired quality of life (QoL) is prevalent among patients with chronic thromboembolic pulmonary hypertension (CTEPH) despite improved survival due to medical advances. We clarified the physical QoL of patients with CTEPH with mildly elevated pulmonary hemodynamics and evaluated its determinants using a database of patients with CTEPH evaluated for hemodynamics during exercise.

METHODS:

The QoL was measured in 144 patients with CTEPH (age, 66 (58-73) years; men/women, 48/96) with mildly elevated mean pulmonary artery pressure (<30 mm Hg) at rest after treatment with balloon pulmonary angioplasty and/or pulmonary endarterectomy using the Short-Form 36 (SF-36) questionnaire. The enrolled patients were divided into 2 groups physical component summary (PCS) scores in the SF-36 over 50 as PCS-good and those under 50 as PCS-poor.

RESULTS:

The median PCS in SF-36 score was 43.4 (IQR 32.4-49.5) points. The PCS-poor group (n = 110) was older and had lower exercise capacity and SaO2 during exercise. PCS scores were correlated with 6-minute walk distance (rs=0.40, p < 0.001), quadriceps strength (rs=0.34, p < 0.001), peak VO2 (rs=0.31, p < 0.001), SaO2 at rest (rs=0.35, p < 0.001) and peak exercise (rs=0.33, p < 0.001), home oxygen therapy usage (rs=-0.28, p = 0.001), and pulmonary vascular resistance at peak exercise (rs=-0.26, p = 0.002).

CONCLUSIONS:

The impairment of physical QoL was common in patients with CTEPH with improved hemodynamics; exercise capacity, hypoxemia, and hemodynamic status during exercise were related to the physical QoL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Embolia Pulmonar / Calidad de Vida / Endarterectomía / Prueba de Esfuerzo / Hipertensión Pulmonar Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Heart Lung Transplant Asunto de la revista: CARDIOLOGIA / TRANSPLANTE Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Embolia Pulmonar / Calidad de Vida / Endarterectomía / Prueba de Esfuerzo / Hipertensión Pulmonar Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Heart Lung Transplant Asunto de la revista: CARDIOLOGIA / TRANSPLANTE Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos